{"id":"W2008380006","doi":"10.1074/jbc.m109.035170","title":"Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alternative complement pathway; Complement receptor; Phage display; Complement system; Cell biology; Classical complement pathway; Single-domain antibody; Immunogenicity; Biology; Antibody; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002165488,0.0001462239,0.0003486855,0.0000235798,0.00005980648,0.0000103315,0.0002752266,0.0001646565,0.002094689],"category_scores_gemma":[0.0001769346,0.0000978769,0.0001695442,0.00006686241,0.00009288052,0.00003143778,0.00002431335,0.0002360792,0.000004258312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006080752,"about_ca_system_score_gemma":0.00006084633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002492133,"about_ca_topic_score_gemma":1.47801e-7,"domain_scores_codex":[0.9988368,0.0001292545,0.0006425033,0.0001391246,0.00006584262,0.000186543],"domain_scores_gemma":[0.9987097,0.0002095854,0.0007621068,0.0001519323,0.0001329094,0.00003379256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006760326,0.0002985013,0.001360198,0.00002784564,0.00006589073,0.000001024318,0.00001344668,0.000007187893,0.9917563,0.00001089978,0.002160873,0.003621826],"study_design_scores_gemma":[0.001837481,0.0005272732,0.01292161,0.00005263016,0.00003956786,0.00002372652,0.00006882337,0.000005161694,0.9818622,0.0001075941,0.002437319,0.0001166425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969357,0.001963635,0.000353746,0.0002821627,0.0001431354,0.0001212662,0.0001265834,0.00001591515,0.00005782761],"genre_scores_gemma":[0.9993722,0.000009749667,0.0002436083,0.0001325221,0.00006302612,0.000001006718,0.0001552902,0.000003601114,0.00001894852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01156142,"threshold_uncertainty_score":0.9988175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0233485789333394,"score_gpt":0.2684540759512063,"score_spread":0.2451054970178669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}