{"id":"W2008380006","doi":"10.1074/jbc.m109.035170","title":"Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alternative complement pathway; Complement receptor; Phage display; Complement system; Cell biology; Classical complement pathway; Single-domain antibody; Immunogenicity; Biology; Antibody; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026708,0.0004518575,0.000428872,0.0002665599,0.0001495706,0.0004849808,0.000378388,0.000351481,0.0009894619],"category_scores_gemma":[0.0002627797,0.0001764977,0.0002655651,0.0002982179,0.0002457518,0.0002023375,0.0003704597,0.0006124974,0.0005542331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008052081,"about_ca_system_score_gemma":0.0002513962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180085,"about_ca_topic_score_gemma":0.001315245,"domain_scores_codex":[0.9997856,0.00003667714,0.00001384892,0.00003142822,0.000065872,0.00006652427],"domain_scores_gemma":[0.9999285,0.00001441578,0.00001676189,0.00000909209,0.00001408514,0.00001713209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005735338,0.00003837696,0.0001258665,0.00001674825,0.000005691885,0.0000357477,0.000009665654,0.0004522129,0.9956763,0.000174694,0.00006454117,0.003342717],"study_design_scores_gemma":[0.00003085267,0.000421196,0.0006501448,0.000003880581,0.00002714463,0.0003769939,0.00001005081,0.002855966,0.9925498,0.00006000354,0.003005689,0.000008392126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981434,0.002231274,0.01313656,0.0002280877,0.00002142129,0.00008814807,0.0001985588,0.0002197032,0.002442338],"genre_scores_gemma":[0.9861525,0.0008819607,0.01075641,0.0001049904,0.000007367919,0.00002948871,0.0002979652,0.00003853069,0.001730692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180085,"threshold_uncertainty_score":0.005842268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0233485789333394,"score_gpt":0.2684540759512063,"score_spread":0.2451054970178669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}