{"id":"W2008421466","doi":"10.1083/jcb.151.1.117","title":"Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy","year":2000,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":395,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Heart Association; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; GSK-3; Regulator; Glycogen synthase; Glycogen; Cell biology; Kinase; GSK3B; Biochemistry; ATP synthase; Glycogen debranching enzyme; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003677827,0.0001498227,0.0002866556,0.00004017336,0.0000541011,0.00000442866,0.0004357444,0.000144473,0.0002794661],"category_scores_gemma":[0.0001021367,0.00009874183,0.0002533841,0.00009296793,0.0002958635,0.000003083983,0.00005834977,0.0001319478,0.00001480739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000148888,"about_ca_system_score_gemma":0.0001475044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001492626,"about_ca_topic_score_gemma":6.26842e-7,"domain_scores_codex":[0.9988495,0.0003057716,0.0003891263,0.0001403916,0.0001136969,0.0002015583],"domain_scores_gemma":[0.9989116,0.00007854098,0.0003141332,0.0003993405,0.0001967804,0.0000995978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001251378,0.00007151051,0.0001367792,0.00001095326,0.0001612461,0.00001096643,0.000130654,0.0001703715,0.9942801,0.00000875359,0.001105484,0.002661802],"study_design_scores_gemma":[0.0007884909,0.000861279,0.0001444802,0.00001586641,0.0001412015,0.00008297998,0.00005903616,0.00001410472,0.9810998,0.0004234787,0.01625869,0.0001106052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944218,0.003347526,0.0001090621,0.0001292646,0.0001229909,0.00009431099,0.00006381348,0.000002954581,0.001708245],"genre_scores_gemma":[0.9980004,0.0005077451,0.0004193149,0.0003785931,0.0003272034,0.000001850381,0.000006889043,0.0000175235,0.0003404171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01515321,"threshold_uncertainty_score":0.4026575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008216944926145102,"score_gpt":0.2300252708776618,"score_spread":0.2218083259515166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}