{"id":"W2008423993","doi":"10.1177/0091270003261078","title":"Effects of St. John's Wort (<i>Hypericum perforatum</i>) on Tacrolimus Pharmacokinetics in Healthy Volunteers","year":2003,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources","keywords":"Pharmacokinetics; Hypericum perforatum; Tacrolimus; Pharmacology; CYP3A; Volume of distribution; Medicine; Pharmacokinetic interaction; Oral administration; Dosing; Drug interaction; Chemistry; Transplantation; Metabolism; Internal medicine; Cytochrome P450","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01056599,0.0005094061,0.001618436,0.000439139,0.0001909416,0.00001116156,0.001141788,0.0005668745,0.001267098],"category_scores_gemma":[0.001187901,0.000369657,0.0005689119,0.0007719733,0.0008575569,0.0001312393,0.0001336335,0.004480775,0.00006560674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009048108,"about_ca_system_score_gemma":0.0006832225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009477145,"about_ca_topic_score_gemma":0.000004659571,"domain_scores_codex":[0.9872298,0.007596173,0.003208016,0.0003889688,0.0005833754,0.0009937291],"domain_scores_gemma":[0.9887505,0.007982261,0.0017545,0.0002843744,0.0004872588,0.0007411151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.07968273,0.02126916,0.04709026,0.0009936339,0.00453655,0.00198053,0.002903951,0.05265424,0.493739,0.001833678,0.228347,0.06496928],"study_design_scores_gemma":[0.03799365,0.00494389,0.01368843,0.00008119456,0.002659868,0.0003081566,0.0002007534,0.00290845,0.2308082,0.0008885057,0.7048169,0.000701944],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679263,0.007708369,0.00008217316,0.00233185,0.01842721,0.0008276531,0.00002934679,0.00002065156,0.002646497],"genre_scores_gemma":[0.9563897,0.02211204,0.0001969944,0.01923425,0.001785718,0.00002081847,0.000001995393,0.00006245154,0.0001959768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.47647,"threshold_uncertainty_score":0.9998755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09962250996604795,"score_gpt":0.4859302468162513,"score_spread":0.3863077368502034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}