{"id":"W2008424354","doi":"10.1038/sj.gene.6364211","title":"Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3′ +6230G&gt;A polymorphism","year":2005,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Biology; Single-nucleotide polymorphism; Genetics; Linkage disequilibrium; Allele; Gene isoform; Locus (genetics); Polyadenylation; SNP; Exon; Gene; Primer extension; Alternative splicing; Complementary DNA; Molecular biology; Genotype; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007706959,0.0001338729,0.0001168498,0.00002187629,0.0004675557,0.00002278987,0.0002087419,0.0001182233,0.0000241329],"category_scores_gemma":[0.0001197178,0.00008689491,0.00009644285,0.000100559,0.0001114532,0.000006435937,0.0002333652,0.0001023083,0.000003218905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003727477,"about_ca_system_score_gemma":0.00004708501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001088601,"about_ca_topic_score_gemma":0.0001240266,"domain_scores_codex":[0.9988257,0.0004510046,0.0001770651,0.0001404459,0.0002302366,0.0001755709],"domain_scores_gemma":[0.9991183,0.00004249635,0.0001561173,0.000552417,0.0001052727,0.00002543918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004354373,0.00006705405,0.001328324,0.00001206154,0.00008013538,2.669144e-8,0.0002552731,0.0009660893,0.8900929,0.00002952153,0.0005879596,0.1065371],"study_design_scores_gemma":[0.001272192,0.000202353,0.1672391,0.00005202522,0.000153205,0.000002418193,0.0002301879,0.001795312,0.8148416,0.0002070844,0.01381129,0.0001931429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880069,0.009815071,0.00001989217,0.001017911,0.0001167262,0.0003012175,0.00001273182,0.000006864464,0.0007027242],"genre_scores_gemma":[0.9983429,0.0005803963,0.00002553343,0.0003736657,0.0001001637,0.00001826232,0.0001058401,0.00001416272,0.0004391335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1659108,"threshold_uncertainty_score":0.3596107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018445175781328,"score_gpt":0.2364374907305492,"score_spread":0.2262530389727359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}