{"id":"W2008469587","doi":"10.1016/j.bbrc.2006.08.160","title":"Structure of human protein kinase C eta (PKCη) C2 domain and identification of phosphorylation sites","year":2006,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"VINNOVA; Wellcome Trust; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Genome Canada","keywords":"Autophosphorylation; Protein kinase C; Diacylglycerol kinase; Gene isoform; Phosphorylation; C2 domain; Serine; Biochemistry; Kinase; Protein kinase domain; Protein kinase A; Chemistry; Binding site; Biology; Cell biology; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002845743,0.00009384403,0.0001332926,0.00006907884,0.0001769014,0.00002220282,0.0002458669,0.0001281608,0.000005237538],"category_scores_gemma":[0.0001274692,0.00008500405,0.0000454274,0.0002252877,0.0008781027,0.000007746775,0.0002700566,0.0001465171,5.232976e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009575975,"about_ca_system_score_gemma":0.00003375832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009096007,"about_ca_topic_score_gemma":0.00001562468,"domain_scores_codex":[0.9989229,0.0001569199,0.0003109315,0.0002291327,0.0002362853,0.0001437876],"domain_scores_gemma":[0.9988872,0.00004199475,0.0001191577,0.0005954023,0.0002924977,0.00006371029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000339985,0.0001475744,0.0002662553,0.00006745177,0.00001034376,8.789754e-8,0.00001889501,5.933106e-7,0.9838514,0.01501772,0.00007917848,0.0005065138],"study_design_scores_gemma":[0.0002451674,0.0001070226,0.005017344,0.00003620501,0.000007631954,7.825129e-7,0.00003613662,0.0001537744,0.9827881,0.01122774,0.0002936353,0.00008645346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997217,0.001790393,0.0001625945,0.000341408,0.000002667224,0.0003165464,0.0000714132,0.000006005392,0.00009196313],"genre_scores_gemma":[0.9978253,0.00008259486,0.001459739,0.00000509751,0.00004941726,0.00002158725,0.0004788059,0.000008791646,0.00006865598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004751089,"threshold_uncertainty_score":0.3466364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0286530473066405,"score_gpt":0.3289983860574749,"score_spread":0.3003453387508345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}