{"id":"W2008477360","doi":"10.1074/jbc.m305200200","title":"Deletions of Any Single Residues in Glu40-Ser48 Loop Connecting A Domain and the First Transmembrane Helix of Sarcoplasmic Reticulum Ca2+-ATPase Result in Almost Complete Inhibition of Conformational Transition and Hydrolysis of Phosphoenzyme Intermediate","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic and rare skin diseases.","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Transmembrane domain; Endoplasmic reticulum; ATP hydrolysis; Mutagenesis; Chemistry; Mutant; Conformational change; Biophysics; ATPase; Stereochemistry; Helix (gastropod); Transmembrane protein; Loop (graph theory); Crystallography; Biochemistry; Enzyme; Biology; Membrane; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043914,0.0004788588,0.0002516737,0.0001151675,0.0001201691,0.0001670857,0.0002466403,0.0003339282,0.00117118],"category_scores_gemma":[0.0002325165,0.0001699753,0.0003125205,0.0001116579,0.0002861054,0.0001727767,0.0002302227,0.0003303378,0.0005356715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177893,"about_ca_system_score_gemma":0.0001021282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002350168,"about_ca_topic_score_gemma":0.0002409549,"domain_scores_codex":[0.9999044,0.00001896261,0.00001766744,0.00002842615,0.00001613827,0.00001451953],"domain_scores_gemma":[0.9997506,0.00005857946,0.0001125662,0.00002940405,0.000009887829,0.00003888878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002700093,0.00003487647,0.0005868148,0.00003318039,0.00001572686,0.0002324221,0.00001923763,0.0002119435,0.997153,0.00007669491,0.00001860135,0.001347468],"study_design_scores_gemma":[0.0001200016,0.0009265485,0.01128432,0.00001703189,0.00009903185,0.003139162,0.00005465492,0.001919239,0.9789566,0.0001679859,0.003297264,0.00001806361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975421,0.0002945248,0.001519384,0.00001804325,0.00001478695,0.00001732331,0.0001927123,0.00003640367,0.0003647808],"genre_scores_gemma":[0.9975839,0.0001874073,0.001420546,0.00001792579,0.000006093441,0.00001886452,0.0003695045,0.00001781943,0.0003780446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117118,"threshold_uncertainty_score":0.003917933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008445054236799907,"score_gpt":0.2065050609506746,"score_spread":0.1980600067138747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}