{"id":"W2008507352","doi":"10.1021/jo034739d","title":"Efficient Synthesis of Enantiopure Pyrrolizidinone Amino Acid","year":2003,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Enantiopure drug; Dipeptide; Stereochemistry; Aldehyde; Carboxylate; Iodide; Proton NMR; Amino acid; Carboxylic acid; Yield (engineering); Catalysis; Enantioselective synthesis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005518094,0.0001380419,0.0002739146,0.00001489071,0.00005131357,0.000007845434,0.0003504728,0.0001214873,0.0005752356],"category_scores_gemma":[0.0007647262,0.00008771315,0.0002495426,0.000145184,0.000111785,0.000001305372,0.00005208237,0.0001405626,0.000003080326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001980224,"about_ca_system_score_gemma":0.00009020227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001145202,"about_ca_topic_score_gemma":5.060625e-7,"domain_scores_codex":[0.9989864,0.00006115455,0.0004309804,0.0001139091,0.0002377189,0.0001698218],"domain_scores_gemma":[0.9989358,0.00006053941,0.0004309023,0.0003357959,0.000153275,0.00008375051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004460374,0.0001109217,0.0002277821,0.00003199244,0.000159196,0.000002189561,0.00002365193,0.00004177673,0.9987978,0.000003054637,0.0002418117,0.0003151842],"study_design_scores_gemma":[0.0002098698,0.0000222916,0.00009469522,0.00003776701,0.0002195094,0.0001947654,0.000200745,0.000008858784,0.9975125,0.00001876005,0.001379121,0.000101069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960473,0.001949264,0.0004709687,0.0001441718,0.00003129362,0.00002410744,0.000005183192,0.000002110636,0.001325571],"genre_scores_gemma":[0.9990892,0.0003620948,0.000176631,0.00002482253,0.0001386164,6.368661e-7,0.000001340547,0.00001689242,0.0001897516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003041884,"threshold_uncertainty_score":0.6298427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00456376189807579,"score_gpt":0.2002518694456168,"score_spread":0.195688107547541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}