{"id":"W2008540208","doi":"10.1371/journal.pone.0098207","title":"Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":282,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Lakehead University","keywords":"Metformin; Oxidative stress; Apoptosis; MCF-7; Cell cycle; Viability assay; Protein kinase B; Chemistry; MTT assay; AMPK; Cancer cell; Cell growth; Endocrinology; Cancer research; Internal medicine; Biology; Medicine; Insulin; Cancer; Protein kinase A; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404881,0.0002829239,0.0003409346,0.0004141651,0.0002448367,0.0001758852,0.0001184612,0.0002078803,0.0009805715],"category_scores_gemma":[0.0000702463,0.0001619057,0.0003817698,0.0003144152,0.0001159668,0.0001315851,0.00009887646,0.0004900456,0.0002364136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003033173,"about_ca_system_score_gemma":0.0002702856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001475721,"about_ca_topic_score_gemma":0.002449352,"domain_scores_codex":[0.9998897,0.00001277317,0.00001274898,0.00001565064,0.00003948397,0.00002962627],"domain_scores_gemma":[0.9999565,0.000005739088,0.0000152629,0.000003951288,0.00001040779,0.000008166944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003858203,0.0001027888,0.0005157779,0.0001118333,0.00001615428,0.00010793,0.00003228511,0.00006357476,0.9954898,0.00009766615,0.0002169004,0.002859523],"study_design_scores_gemma":[0.0001210167,0.001256123,0.01980294,0.00002293612,0.00006818756,0.0004999094,0.00009666439,0.001250078,0.9689016,0.0001324495,0.007836121,0.00001193306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829212,0.01122443,0.001706301,0.0004986384,0.0001783898,0.00004656444,0.0008880133,0.00009407226,0.002442469],"genre_scores_gemma":[0.9820215,0.00857095,0.002966784,0.0003724865,0.00005909564,0.0001338587,0.001994795,0.00001733923,0.003863162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475721,"threshold_uncertainty_score":0.003280401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008777762513568169,"score_gpt":0.2035435693184802,"score_spread":0.194765806804912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}