{"id":"W2008552879","doi":"10.1038/mt.2014.53","title":"Multicenter Randomized Phase 2 Clinical Trial of a Recombinant Human Endostatin Adenovirus in Patients with Advanced Head and Neck Carcinoma","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kane Biotech (Canada)","funders":"","keywords":"Recombinant DNA; Medicine; Head and neck; Carcinoma; Oncology; Head and neck cancer; Virology; Internal medicine; Surgery; Biology; Radiation therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003278765,0.001793587,0.002596814,0.0003716001,0.0003736448,0.0008931014,0.0007330861,0.001392995,0.004379799],"category_scores_gemma":[0.002202448,0.0007454409,0.00127485,0.0003717864,0.001083544,0.0009114028,0.0004416249,0.002445175,0.0006456003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008682109,"about_ca_system_score_gemma":0.001732818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008346551,"about_ca_topic_score_gemma":0.002063511,"domain_scores_codex":[0.9989465,0.0007186476,0.00004001514,0.0001270226,0.00006409996,0.0001037516],"domain_scores_gemma":[0.9989058,0.0003380448,0.0002110166,0.0001074582,0.00008352364,0.0003542424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9700266,0.01406092,0.0006927882,0.0001979945,0.0003209963,0.00003560301,0.00004278367,0.0003721258,0.003860849,0.0001029701,0.000639266,0.009647191],"study_design_scores_gemma":[0.8981134,0.09984181,0.0007914653,0.000007220104,0.00009853341,0.000018255,0.00001016929,0.0003728438,0.0003304407,0.00005740359,0.0003507168,0.000007859407],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989461,0.001438995,0.0006793315,0.0005545978,0.0004329072,0.005845962,0.0006495156,0.00007109698,0.0008665426],"genre_scores_gemma":[0.9741178,0.001853389,0.003451208,0.001302808,0.0005924993,0.01398963,0.001419612,0.00002783955,0.003245249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004379799,"threshold_uncertainty_score":0.01733994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165984299141586,"score_gpt":0.3560348366483846,"score_spread":0.3343749936569687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}