{"id":"W2008552879","doi":"10.1038/mt.2014.53","title":"Multicenter Randomized Phase 2 Clinical Trial of a Recombinant Human Endostatin Adenovirus in Patients with Advanced Head and Neck Carcinoma","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kane Biotech (Canada)","funders":"","keywords":"Recombinant DNA; Medicine; Head and neck; Carcinoma; Oncology; Head and neck cancer; Virology; Internal medicine; Surgery; Biology; Radiation therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009689281,0.0002268056,0.000587824,0.00009136455,0.00004319366,0.00001628436,0.0001985937,0.0001299338,0.00001606129],"category_scores_gemma":[0.0001436054,0.0001770068,0.0001575117,0.00009550884,0.0002505548,0.000005345484,0.00005193851,0.0001636686,0.000001560821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001095815,"about_ca_system_score_gemma":0.00005144687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003319087,"about_ca_topic_score_gemma":0.00004980506,"domain_scores_codex":[0.9973403,0.001037587,0.0005853793,0.0004745523,0.0002552797,0.0003068555],"domain_scores_gemma":[0.9990086,0.00006663868,0.0002028713,0.0004983316,0.0001152628,0.0001082798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7905484,0.001519374,0.006079987,0.000008962043,0.0001088434,0.000004579214,0.00005686299,0.000007912065,0.1675479,0.00001247358,0.000007156677,0.03409751],"study_design_scores_gemma":[0.80861,0.03100025,0.002968627,0.00002226055,0.00001248143,3.898784e-7,0.000006443107,0.00006561941,0.1566542,0.00004506704,0.0004231394,0.0001914616],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971141,0.0005319741,0.0002631445,0.00005009013,0.00008816277,0.001886148,0.000007315988,0.000006443427,0.00005268624],"genre_scores_gemma":[0.9986593,0.0002201959,0.0005140411,0.0002650394,0.00003574606,0.0001259517,0.0001022454,0.00004647083,0.00003104496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03390605,"threshold_uncertainty_score":0.7218127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165984299141586,"score_gpt":0.3560348366483846,"score_spread":0.3343749936569687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}