{"id":"W2008584420","doi":"10.1038/nm.2313","title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":544,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; University of Ottawa; University of California, Irvine; CHDI Foundation","keywords":"Huntingtin; Huntingtin Protein; Mitochondrial fission; Neurodegeneration; Huntington's disease; Biology; Cell biology; Mitochondrion; GTPase; Mutant; Genetics; Disease; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288602,0.0002937581,0.0002920589,0.000131325,0.0003107794,0.00002318464,0.000344278,0.0001981864,0.0002994832],"category_scores_gemma":[0.0074998,0.0001650052,0.0000509121,0.0004708887,0.0004160189,0.0001132054,0.0001501892,0.0007660689,0.00002060768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002253687,"about_ca_system_score_gemma":0.00006847045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000501022,"about_ca_topic_score_gemma":0.00001535966,"domain_scores_codex":[0.9976627,0.0005228096,0.0002838156,0.0006027921,0.0005991847,0.0003286725],"domain_scores_gemma":[0.9986073,0.0004304649,0.0002197758,0.0004370587,0.00008622147,0.0002191542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001717753,0.0001619005,0.0001887795,0.00004185022,0.000006796103,0.00006138131,0.0004808592,7.044519e-7,0.9964308,0.0004484832,0.0002340089,0.001772711],"study_design_scores_gemma":[0.001267235,0.0003613753,0.01366451,0.0001869253,0.00007461936,0.00005223375,0.00006801442,0.0005651735,0.982878,0.0004407775,0.0002571872,0.0001839357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950862,0.0004764728,0.00002612763,0.001651003,0.0005721203,0.001034001,0.00002417881,0.00009174483,0.001038147],"genre_scores_gemma":[0.9980965,0.00002948507,0.00008739355,0.0009206262,0.0002390066,0.00006382332,0.000004141252,0.00003068827,0.0005282859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01355274,"threshold_uncertainty_score":0.8978503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328208117488196,"score_gpt":0.263803529589483,"score_spread":0.240521448414601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}