{"id":"W2008603261","doi":"10.1159/000315103","title":"Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature","year":2010,"lang":"en","type":"review","venue":"Cellular Physiology and Biochemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Caveolae; Cell biology; Vascular permeability; Signal transduction; Nitric oxide; Pulmonary edema; Biology; Endothelium; Sphingomyelin; Ceramide; Lipid signaling; Cell signaling; Endothelial dysfunction; Nitric oxide synthase; Immunology; Inflammation; Internal medicine; Medicine; Endocrinology; Lung; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665493,0.0002306015,0.0004176698,0.0004592886,0.0001883844,0.0007198594,0.0003545957,0.0004533643,0.0004578356],"category_scores_gemma":[0.0002250433,0.0000913593,0.0002091763,0.0003416595,0.0005655255,0.0009139555,0.0003354975,0.0006225057,0.0001690483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004522135,"about_ca_system_score_gemma":0.0005634301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003936356,"about_ca_topic_score_gemma":0.0004900348,"domain_scores_codex":[0.9999026,0.00002157612,0.00001135399,0.00002403224,0.00002086168,0.00001961615],"domain_scores_gemma":[0.9999428,0.00001624584,0.00001125971,0.000003573594,0.00001678402,0.000009413657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007948948,0.00007171718,0.001524746,0.01989032,0.0002608783,0.001825494,0.0007461205,0.001844345,0.3253521,0.06306757,0.01014414,0.5744777],"study_design_scores_gemma":[0.00005767703,0.0006080527,0.01090004,0.002707494,0.000433135,0.00612774,0.0008951967,0.001715904,0.1089143,0.03142494,0.8361204,0.00009511384],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01294892,0.9815341,0.001714607,0.001383642,0.0004340215,0.00000869723,0.00005485864,0.00002379547,0.001897447],"genre_scores_gemma":[0.0867807,0.9091527,0.001163078,0.0007057421,0.0005781524,0.0000257494,0.00008916223,0.000005967257,0.001498672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0007198594,"threshold_uncertainty_score":0.003281116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004336492858226998,"score_gpt":0.2108578905195533,"score_spread":0.2065213976613264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}