{"id":"W2008603261","doi":"10.1159/000315103","title":"Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature","year":2010,"lang":"en","type":"review","venue":"Cellular Physiology and Biochemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"Caveolae; Cell biology; Vascular permeability; Signal transduction; Nitric oxide; Pulmonary edema; Biology; Endothelium; Sphingomyelin; Ceramide; Lipid signaling; Cell signaling; Endothelial dysfunction; Nitric oxide synthase; Immunology; Inflammation; Internal medicine; Medicine; Endocrinology; Lung; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005897988,0.0005955825,0.0009883494,0.00004178541,0.0002344079,0.0000740184,0.00028346,0.001188796,0.000002966367],"category_scores_gemma":[0.00005763287,0.0003806816,0.0001560212,0.0001576582,0.0003688805,0.00001408896,0.0001694612,0.0007362476,7.080395e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008913665,"about_ca_system_score_gemma":0.00007870697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001473307,"about_ca_topic_score_gemma":0.000001355241,"domain_scores_codex":[0.9975573,0.0004216279,0.0004013107,0.001045528,0.0001416692,0.0004326045],"domain_scores_gemma":[0.9987407,0.00009269895,0.0002780095,0.0006779334,0.00005866789,0.0001519519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007537253,0.00005908747,0.0001335157,0.008602388,0.0002476973,0.00002130081,0.00004899187,0.00001190516,0.9636094,0.0000258873,0.00008013028,0.02708435],"study_design_scores_gemma":[0.004242641,0.0009808519,0.001120593,0.01496776,0.006290205,0.003281721,0.000297092,0.0008175793,0.1416441,0.000665605,0.8196195,0.006072315],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2876881,0.7116711,0.00005161409,0.000002844889,0.0000825687,0.0004510232,0.00002140683,0.000009907006,0.00002147979],"genre_scores_gemma":[0.2376575,0.7588021,0.0001560632,0.00007766955,0.001156741,0.0001171794,0.00190707,0.00005959123,0.00006614275],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8219653,"threshold_uncertainty_score":0.9998645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004336492858226998,"score_gpt":0.2108578905195533,"score_spread":0.2065213976613264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}