{"id":"W2008626955","doi":"10.1002/humu.20702","title":"K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population","year":2008,"lang":"en","type":"article","venue":"Human Mutation","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; McGill University and Génome Québec Innovation Centre; McGill University","funders":"","keywords":"Farnesyl-diphosphate farnesyltransferase; Squalene; Biology; Cholesterol; Genetics; Population; Single-nucleotide polymorphism; Squalene monooxygenase; ATP synthase; Gene; Biochemistry; Enzyme; Molecular biology; Farnesyltransferase; Biosynthesis; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007667745,0.001184149,0.0006239527,0.001286532,0.003794889,0.001237158,0.0009260883,0.0009855311,0.003425786],"category_scores_gemma":[0.001506224,0.0004331944,0.0008532716,0.001712325,0.0008974245,0.0002090417,0.0005484795,0.0006721597,0.0002206129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00589555,"about_ca_system_score_gemma":0.004402428,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9307321,"about_ca_topic_score_gemma":0.9101266,"domain_scores_codex":[0.9990593,0.0001119119,0.00005340626,0.0003643981,0.0001942433,0.0002168878],"domain_scores_gemma":[0.9992768,0.0001020981,0.0001097399,0.00005869281,0.0002666611,0.0001859499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009203203,0.0001863631,0.9762071,0.00004890098,0.0004090812,0.002426299,0.003753908,0.0001703391,0.0051618,0.0004223877,0.00150761,0.008785871],"study_design_scores_gemma":[0.00008712827,0.0001153086,0.9952252,0.00002870072,0.000173877,0.001078863,0.001114136,0.0004720128,0.0002106046,0.00008816709,0.001375761,0.00003028002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980416,0.0002451388,0.0001930531,0.0001674848,0.00001087238,0.00002810164,0.0004071065,0.00001099947,0.0008956071],"genre_scores_gemma":[0.9982747,0.000127817,0.0002063277,0.0001242534,0.000009374036,0.00001273856,0.0002869277,0.000008472241,0.0009494471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06926793,"threshold_uncertainty_score":0.1393517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.031606369790245,"score_gpt":0.2783865141029399,"score_spread":0.2467801443126949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}