{"id":"W2008650353","doi":"10.1158/1078-0432.mechres-b32","title":"Abstract B32: Impact of Lipid-Substitution on Assembly and Delivery of siRNA by Cationic Polymers","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Transfection; Small interfering RNA; Polymer; Chemistry; In vitro; Biochemistry; Cationic polymerization; In vivo; Combinatorial chemistry; Biology; Gene; Organic chemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452444,0.0004519002,0.0001781131,0.0001967497,0.0001114633,0.0002416403,0.0001563278,0.0002915387,0.001564757],"category_scores_gemma":[0.0004090643,0.0001773781,0.0001391732,0.0002264989,0.0001284165,0.0002040579,0.0001573738,0.0002693702,0.0005475096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707905,"about_ca_system_score_gemma":0.000175026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004596657,"about_ca_topic_score_gemma":0.0003764121,"domain_scores_codex":[0.9997963,0.00004531801,0.00002294125,0.00004691468,0.00004290951,0.00004562312],"domain_scores_gemma":[0.999755,0.00006129484,0.00007447771,0.0000137491,0.00004456196,0.00005093587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001044106,0.00001768924,0.00004933055,0.0000300565,0.000003634,0.00002180834,0.000009961913,0.00008759602,0.9990281,0.000009916102,0.00001404485,0.0006234071],"study_design_scores_gemma":[0.000007303662,0.0003192655,0.000679875,0.000004120443,0.000005583829,0.00002781557,0.00000447161,0.0002476191,0.9982073,0.000003603417,0.0004893212,0.000003796509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966354,0.0007054401,0.001040877,0.00002993024,0.00001175921,0.00004086817,0.000133503,0.0000400368,0.001362086],"genre_scores_gemma":[0.9946792,0.0004060615,0.002191514,0.00003103124,0.000005244397,0.00005487191,0.0003483515,0.00004839613,0.002235384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564757,"threshold_uncertainty_score":0.005234659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1328208918245548,"score_gpt":0.4889012117126326,"score_spread":0.3560803198880778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}