{"id":"W2008680963","doi":"10.1038/labinvest.3700366","title":"Lipopolysaccharide signaling in endothelial cells","year":2005,"lang":"en","type":"review","venue":"Laboratory Investigation","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":613,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"TLR4; Cell biology; CD14; Toll-like receptor; Innate immune system; Signal transduction; Proinflammatory cytokine; Lipopolysaccharide; Receptor; Biology; Signal transducing adaptor protein; Inflammation; Pattern recognition receptor; Tumor necrosis factor alpha; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001140691,0.001665409,0.001604591,0.001962375,0.0003596576,0.001668737,0.001308242,0.002073033,0.002912941],"category_scores_gemma":[0.0009088239,0.0004633797,0.0004069471,0.002021707,0.001023639,0.002092114,0.001003664,0.003191215,0.00340235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009931197,"about_ca_system_score_gemma":0.001593901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008570836,"about_ca_topic_score_gemma":0.001823061,"domain_scores_codex":[0.9997664,0.00003630474,0.00003876254,0.00004239223,0.00008857006,0.00002759247],"domain_scores_gemma":[0.9995514,0.0001387238,0.00005931125,0.00002308263,0.0001575927,0.00006982438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001751173,0.00009079812,0.0001446225,0.005787971,0.00004316031,0.0003673305,0.00003591229,0.0003395725,0.005474415,0.003725053,0.06910598,0.9147101],"study_design_scores_gemma":[0.00003915481,0.00007936175,0.0004002537,0.001498294,0.00006494643,0.0009311712,0.00003803855,0.00009575667,0.001369323,0.001794069,0.9936715,0.00001807147],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001216117,0.9960367,0.0004512662,0.0006411707,0.001406728,0.000008555625,0.0000229512,0.00001603248,0.001294968],"genre_scores_gemma":[0.0007129005,0.9952297,0.0004820585,0.0005622352,0.001098882,0.00001223542,0.00005184281,0.00000226604,0.001847908],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002912941,"threshold_uncertainty_score":0.009744763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840871407149236,"score_gpt":0.281005791088546,"score_spread":0.2525970770170536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}