{"id":"W2008708488","doi":"10.1182/blood-2008-09-178301","title":"Surface RANKL of Toll-like receptor 4–stimulated human neutrophils activates osteoclastic bone resorption","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"RANKL; Bone resorption; Cancer research; Receptor; Toll-like receptor; Osteoclast; Chemistry; Medicine; Internal medicine; Immunology; Cell biology; Biology; Innate immune system; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002862705,0.0004369262,0.0001974081,0.0001924182,0.000128153,0.0003850655,0.0001658497,0.0002195404,0.003859726],"category_scores_gemma":[0.0002670109,0.0001776609,0.0001991433,0.0001149484,0.0001755433,0.0001554484,0.0002740666,0.0003831524,0.001350666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003267362,"about_ca_system_score_gemma":0.0002634884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003702856,"about_ca_topic_score_gemma":0.0006320185,"domain_scores_codex":[0.9996949,0.00008403906,0.00001683287,0.00001988579,0.0001043614,0.00007996451],"domain_scores_gemma":[0.999934,0.00001964635,0.0000101625,0.000009897928,0.00001157866,0.00001485461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003828132,0.00004525481,0.0002889431,0.0001189308,0.000005332866,0.0001266719,0.00002410838,0.000061021,0.9942383,0.000281666,0.0002599326,0.004167122],"study_design_scores_gemma":[0.0001894535,0.0006983927,0.00454072,0.00002963391,0.00002021556,0.0008604504,0.00004111911,0.002289704,0.980872,0.0002286011,0.01022246,0.000007308387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821599,0.00737554,0.004698534,0.0003401316,0.00008899616,0.00007651724,0.0004496679,0.0001413397,0.004669333],"genre_scores_gemma":[0.9896162,0.001952078,0.001908949,0.00009506892,0.00003204746,0.0000539465,0.001205061,0.00001779622,0.005118931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003859726,"threshold_uncertainty_score":0.01291209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008088950818122732,"score_gpt":0.2382896809944914,"score_spread":0.2302007301763687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}