{"id":"W2008730180","doi":"10.1080/00498250400015301","title":"Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone","year":2004,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; AstraZeneca (Canada); Université de Montréal","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec","keywords":"CYP3A4; Domperidone; Cytochrome P450; Metabolite; Chemistry; Microsome; Enzyme; Metabolism; Biochemistry; Drug metabolism; Pharmacology; Biology; Endocrinology; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002793193,0.0003360131,0.0003094412,0.0002273215,0.0001425013,0.0002074368,0.00009005305,0.0002290684,0.000816617],"category_scores_gemma":[0.0003770239,0.0001186915,0.000269473,0.0002112524,0.0001273444,0.000166149,0.00008568394,0.0002685743,0.0004772643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964704,"about_ca_system_score_gemma":0.0002468998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361273,"about_ca_topic_score_gemma":0.001376991,"domain_scores_codex":[0.9998554,0.00004528967,0.00001419669,0.0000301807,0.00002852251,0.00002641164],"domain_scores_gemma":[0.9998041,0.00005816657,0.00004894554,0.00001703677,0.00005179213,0.00001994707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003307161,0.00003811511,0.006042425,0.0001197509,0.00002782854,0.0002515822,0.00002745933,0.0001150346,0.9811412,0.00008122131,0.00008583574,0.0117388],"study_design_scores_gemma":[0.00003504425,0.001108957,0.08982362,0.00001826574,0.0001224222,0.001712897,0.00004815852,0.001471957,0.9001437,0.0001975055,0.005307173,0.0000102748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607748,0.01188366,0.02382313,0.0002169566,0.00003257363,0.0001679366,0.0009360347,0.0001599501,0.002005146],"genre_scores_gemma":[0.9773563,0.003352093,0.0161218,0.0000738451,0.00003257159,0.0000547841,0.001079029,0.0000120935,0.001917353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361273,"threshold_uncertainty_score":0.00273186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06427480296366353,"score_gpt":0.3887474671002587,"score_spread":0.3244726641365951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}