{"id":"W2008743836","doi":"10.1074/jbc.m111.293027","title":"Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; University of Ottawa","funders":"Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Heart and Stroke Foundation of Canada","keywords":"TPH2; Dorsal raphe nucleus; 5-HT1A receptor; Raphe nuclei; Serotonergic; Biology; Endocrinology; Internal medicine; Raphe; Serotonin; Autoreceptor; Tryptophan hydroxylase; In situ hybridization; Gene expression; Receptor; 5-HT receptor; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003577805,0.001489917,0.0008597353,0.002077817,0.000455089,0.0007509317,0.0006549194,0.001326276,0.005952485],"category_scores_gemma":[0.0003170874,0.0006891749,0.0008263159,0.0003854263,0.0009959514,0.0004419456,0.0005177359,0.001608968,0.001022712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006519001,"about_ca_system_score_gemma":0.0003069639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009919589,"about_ca_topic_score_gemma":0.001904858,"domain_scores_codex":[0.9993407,0.00005853635,0.00009600908,0.0002404325,0.0001499252,0.0001144029],"domain_scores_gemma":[0.9989522,0.0001509643,0.0004334427,0.00005685173,0.00004584295,0.0003606663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002704456,0.0001243475,0.0001934462,0.00004415366,0.00001815785,0.0002868735,0.0000393252,0.00008828413,0.997911,0.0001692673,0.00004685239,0.0008077406],"study_design_scores_gemma":[0.0005130553,0.001879552,0.02500254,0.00008838188,0.0002513521,0.004247298,0.0002126264,0.002733865,0.9611788,0.000325731,0.003488001,0.00007868588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932426,0.0007743769,0.002644623,0.0001741842,0.00007016722,0.00006327694,0.001956027,0.0003101067,0.0007645628],"genre_scores_gemma":[0.979928,0.001158665,0.006407687,0.0002012032,0.00004654295,0.000162134,0.001998523,0.0002673651,0.009829862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005952485,"threshold_uncertainty_score":0.01991302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04244540045568501,"score_gpt":0.2856748226432774,"score_spread":0.2432294221875924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}