{"id":"W2008743836","doi":"10.1074/jbc.m111.293027","title":"Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; University of Ottawa","funders":"Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Heart and Stroke Foundation of Canada","keywords":"TPH2; Dorsal raphe nucleus; 5-HT1A receptor; Raphe nuclei; Serotonergic; Biology; Endocrinology; Internal medicine; Raphe; Serotonin; Autoreceptor; Tryptophan hydroxylase; In situ hybridization; Gene expression; Receptor; 5-HT receptor; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001128255,0.0004135302,0.001042627,0.0001121858,0.00007845917,0.00002245571,0.000237498,0.0005632961,0.0004385571],"category_scores_gemma":[0.001277451,0.0002759251,0.0002783688,0.0001366827,0.0002789111,0.0002888264,0.0001410132,0.0008839226,0.000009032145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003214752,"about_ca_system_score_gemma":0.0002414746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008073058,"about_ca_topic_score_gemma":3.254732e-7,"domain_scores_codex":[0.9972742,0.0002049914,0.0009940226,0.0004349434,0.0004382534,0.000653546],"domain_scores_gemma":[0.9978,0.0002843156,0.000680618,0.0003510136,0.0002400332,0.0006440006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009221985,0.00029968,0.1442923,0.00008711994,0.00008646934,0.00005462738,0.0002096082,0.000001498015,0.8520988,8.939635e-7,0.0001326314,0.001814258],"study_design_scores_gemma":[0.00230694,0.0001815275,0.429946,0.0001491299,0.00003980356,0.0007565794,0.0001371108,0.00001597838,0.5654669,0.00001699513,0.0007899824,0.0001931194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941984,0.004237773,0.00004975172,0.0005305576,0.0002234697,0.000456055,0.00002159893,0.00004566433,0.0002366617],"genre_scores_gemma":[0.9957213,0.0001158342,0.002570282,0.00013942,0.001195907,0.00002588646,0.00001353398,0.00003071869,0.0001871225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2866319,"threshold_uncertainty_score":0.9999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04244540045568501,"score_gpt":0.2856748226432774,"score_spread":0.2432294221875924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}