{"id":"W2008744352","doi":"10.1158/1535-7163.targ-11-c22","title":"Abstract C22: A phase II study of intravenous wild-type reovirus (Reolysin®) in combination with paclitaxel plus carboplatin in patients with platinum refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Carboplatin; Regimen; Tolerability; Chemotherapy; Phases of clinical research; Oncology; Population; Surgery; Adverse effect; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023446,0.0002342949,0.000320444,0.0001171807,0.00005105269,0.000007550358,0.0001800132,0.00007997498,0.000007291317],"category_scores_gemma":[0.00001082385,0.0001607645,0.00002695299,0.000313914,0.0001581696,0.000009319542,0.00008283385,0.0002206418,6.370325e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006673016,"about_ca_system_score_gemma":0.0002771915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009171618,"about_ca_topic_score_gemma":0.005205065,"domain_scores_codex":[0.9984707,0.0002123065,0.000365339,0.0003569263,0.0003405157,0.0002542528],"domain_scores_gemma":[0.9990706,0.00002023622,0.0002588657,0.0004334742,0.0001632249,0.00005364138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09384774,0.01849265,0.3008537,0.000501318,0.0005401297,0.00008387958,0.0237535,0.0007122812,0.5104532,0.000007256026,0.000003358829,0.05075103],"study_design_scores_gemma":[0.04710853,0.1288574,0.3613458,0.0001696923,0.000245124,0.000004186803,0.001588573,0.0002654158,0.4597737,0.00004067304,0.00003639674,0.0005645116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963467,0.002441939,0.00001342268,0.00001355044,0.00002897483,0.00110087,0.00002668615,0.000002863723,0.00002505915],"genre_scores_gemma":[0.9996066,0.0001142364,0.00009894638,0.00005979625,0.00000489997,0.000049175,0.00001707257,0.00004077151,0.000008493615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1103647,"threshold_uncertainty_score":0.6555784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269678786943771,"score_gpt":0.2977749498705359,"score_spread":0.2650781620010982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}