{"id":"W2008744352","doi":"10.1158/1535-7163.targ-11-c22","title":"Abstract C22: A phase II study of intravenous wild-type reovirus (Reolysin®) in combination with paclitaxel plus carboplatin in patients with platinum refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Carboplatin; Regimen; Tolerability; Chemotherapy; Phases of clinical research; Oncology; Population; Surgery; Adverse effect; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001062451,0.001521894,0.0018911,0.000502997,0.0004699579,0.0008901351,0.001048804,0.001371319,0.003066188],"category_scores_gemma":[0.0006576853,0.0006100682,0.001051383,0.0004273,0.0008461141,0.0006520787,0.0002648904,0.002932543,0.0008363899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009842489,"about_ca_system_score_gemma":0.0017915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002075471,"about_ca_topic_score_gemma":0.004089468,"domain_scores_codex":[0.9996558,0.0001448095,0.0000176045,0.00006775306,0.00003619977,0.00007770505],"domain_scores_gemma":[0.9994494,0.00007559996,0.00008221292,0.00005141545,0.00003838344,0.0003029974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5889704,0.1791543,0.005864034,0.001438325,0.001755676,0.000776315,0.0005505992,0.003859354,0.1175795,0.0003583773,0.003950115,0.09574304],"study_design_scores_gemma":[0.4103893,0.5728136,0.007766514,0.00002677091,0.0002653421,0.0003235177,0.00005566679,0.0009013821,0.005617951,0.00006332139,0.001748674,0.00002807786],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938011,0.001074499,0.0003605938,0.000205466,0.0001005504,0.002628684,0.0005163213,0.00007030402,0.001242482],"genre_scores_gemma":[0.9910493,0.001289156,0.001089672,0.0005106188,0.0001710711,0.0019596,0.001305388,0.0000291859,0.002595998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003066188,"threshold_uncertainty_score":0.01025742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269678786943771,"score_gpt":0.2977749498705359,"score_spread":0.2650781620010982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}