{"id":"W2008760178","doi":"10.1016/j.bcp.2009.07.019","title":"Structure–function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania","year":2009,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Amino acid; Mutant; Biochemistry; Mutagenesis; Major facilitator superfamily; Chemistry; Site-directed mutagenesis; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005535837,0.0002476794,0.0007273455,0.0001116267,0.0001677734,0.000005750219,0.0007786659,0.0001807141,0.0002442907],"category_scores_gemma":[0.000237338,0.0001034277,0.0005886104,0.001342652,0.001157325,0.00003583942,0.0001231213,0.0005574975,8.043855e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007148996,"about_ca_system_score_gemma":0.0001795205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000100051,"about_ca_topic_score_gemma":0.00006053416,"domain_scores_codex":[0.9972378,0.0006327111,0.000702417,0.0003465436,0.0007005196,0.0003800351],"domain_scores_gemma":[0.9982312,0.0001482756,0.0004930036,0.0007625248,0.0002951105,0.00006991033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324072,0.0002238285,0.01220988,0.0001420984,0.001617845,0.000001558737,0.000336779,0.000006424492,0.9781389,0.0001131381,0.005808786,0.00007670275],"study_design_scores_gemma":[0.001105385,0.0001487555,0.3294488,0.00004509438,0.001626768,0.000003864175,0.00004376989,0.00003919953,0.6670696,0.0001288966,0.0002759692,0.00006380475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760197,0.0005471054,0.000005464661,0.01940467,0.0001233645,0.003637893,0.0001029059,0.00001728238,0.0001416129],"genre_scores_gemma":[0.9981735,0.00003897837,0.00003104371,0.001229463,0.0001093545,0.0001661711,0.0000106026,0.00001584886,0.0002250787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.317239,"threshold_uncertainty_score":0.4264212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714582749321017,"score_gpt":0.296121984738439,"score_spread":0.2789761572452288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}