{"id":"W2008764355","doi":"10.1111/j.1349-7006.2008.00742.x","title":"A new transgenic mouse line to image chemically induced p53 activation <i>in vivo</i>","year":2008,"lang":"en","type":"article","venue":"Cancer Science","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Medical Research Council; National Cancer Institute; Institut National Du Cancer; Cancer Research UK; Queen Mary University of London; Institut National de la Santé et de la Recherche Médicale; Johns Hopkins University","keywords":"Luciferase; In vivo; Transgene; Genetically modified mouse; Doxorubicin; In vitro; Cell culture; Biology; Cell biology; DNA damage; Reporter gene; Toxicity; Bioluminescence imaging; Molecular biology; Cancer research; Gene expression; Chemistry; Transfection; DNA; Gene; Biochemistry; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074272,0.001462249,0.0006144233,0.002515998,0.000492771,0.0006551978,0.001202812,0.001508309,0.005882906],"category_scores_gemma":[0.0004704801,0.0007465055,0.0009545548,0.0005642674,0.0007742469,0.0008308213,0.0005456182,0.002679302,0.002881637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005550282,"about_ca_system_score_gemma":0.0004329783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008546982,"about_ca_topic_score_gemma":0.002032766,"domain_scores_codex":[0.9992983,0.0001013971,0.0001174723,0.0002310948,0.0001620048,0.00008967899],"domain_scores_gemma":[0.9990776,0.0001736975,0.0003365997,0.0001161615,0.0001498532,0.0001461978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009656351,0.0001116866,0.000223773,0.00006350334,0.00001262714,0.0001464396,0.00003755394,0.00005340266,0.9949273,0.0006041002,0.0005439912,0.003179119],"study_design_scores_gemma":[0.0001385625,0.0008502179,0.002785571,0.00006039323,0.0001121846,0.00227937,0.00005056791,0.001746929,0.9621718,0.000301264,0.02945949,0.00004366379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5265705,0.005052271,0.4164389,0.003626622,0.001491994,0.002110771,0.01797205,0.01063357,0.01610338],"genre_scores_gemma":[0.547022,0.007300825,0.3282047,0.001624521,0.0003951351,0.004417001,0.03117775,0.003919928,0.07593829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005882906,"threshold_uncertainty_score":0.01968032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796187385075765,"score_gpt":0.2966722293062217,"score_spread":0.268710355455464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}