{"id":"W2008823751","doi":"10.1021/bi201361v","title":"Engineering a Structure Switching Mechanism into a Steroid-Binding Aptamer and Hydrodynamic Analysis of the Ligand Binding Mechanism","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"University of Calgary","keywords":"Aptamer; Chemistry; Ligand (biochemistry); Nuclear magnetic resonance spectroscopy; Isothermal titration calorimetry; Binding site; Folding (DSP implementation); Biophysics; Stereochemistry; Crystallography; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469221,0.0002472983,0.000290877,0.0001321311,0.0001157423,0.00002129684,0.0002557164,0.0002621126,0.000003156247],"category_scores_gemma":[0.00006581073,0.0001918218,0.000213974,0.0004309884,0.0000584676,0.000005996063,0.0002596887,0.0001551149,1.921828e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003126736,"about_ca_system_score_gemma":0.00002652787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003040152,"about_ca_topic_score_gemma":0.00002436214,"domain_scores_codex":[0.9988503,0.00002078931,0.0002762439,0.0004658498,0.0001576885,0.0002290554],"domain_scores_gemma":[0.9991475,0.000009019609,0.0002152326,0.0005040253,0.00005320476,0.00007097606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001443168,0.00001345604,0.0005600353,0.0000385042,0.000544951,0.000001550176,0.0001081125,0.000003960631,0.9983509,0.00007990743,0.000002955026,0.0002812552],"study_design_scores_gemma":[0.000121541,0.00003063187,0.0001951213,0.0000471066,0.0005504262,0.00001391961,0.0001279424,0.002122996,0.9963367,0.0002061706,0.00001197754,0.0002354624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963732,0.0001440813,0.003218452,0.00001428961,0.00004997716,0.00008333904,0.0000368732,0.00003088954,0.00004892671],"genre_scores_gemma":[0.9935312,0.00004874938,0.006158357,0.00003051258,0.00004552173,0.000003887554,0.0000445643,0.00002472279,0.000112523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939906,"threshold_uncertainty_score":0.7822267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005353541604202026,"score_gpt":0.2110181159087221,"score_spread":0.20566457430452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}