{"id":"W2008828299","doi":"10.1074/jbc.m110.213777","title":"CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Kinase; Cell biology; Protein kinase domain; Mutation; Zebrafish; Subfamily; Plasma protein binding; Genetics; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570186,0.0001950066,0.0004033838,0.00006498791,0.00008273162,0.000019607,0.0001066237,0.0001407022,0.0002995889],"category_scores_gemma":[0.00005744767,0.0001138426,0.0001975406,0.0001657328,0.0000598303,0.0000904516,0.00004154557,0.0002102987,0.000006489748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001037064,"about_ca_system_score_gemma":0.00007456054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000152602,"about_ca_topic_score_gemma":7.429291e-7,"domain_scores_codex":[0.9988659,0.00003102498,0.000447822,0.0001819897,0.0002424918,0.0002307652],"domain_scores_gemma":[0.9990081,0.00001368576,0.0003103788,0.0001894828,0.0002129128,0.0002654309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002313312,0.004665922,0.0306929,0.0001802808,0.0008976855,0.002285345,0.0008010345,0.00003891835,0.9545457,0.00007749446,0.00007946065,0.003421935],"study_design_scores_gemma":[0.004322649,0.003197195,0.01973543,0.0004857141,0.000370835,0.005398087,0.0003218552,0.0001188848,0.9653001,0.00009884978,0.0003488041,0.0003015726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940907,0.0001241607,0.00487799,0.0001428601,0.00004260684,0.0002771057,0.000009636416,0.00001807196,0.0004168405],"genre_scores_gemma":[0.9852095,0.00005526129,0.0142874,0.0002350264,0.0001429035,0.00001752631,0.00001988553,0.00001218367,0.00002034341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01095747,"threshold_uncertainty_score":0.4642365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04951131146816076,"score_gpt":0.2632985519373353,"score_spread":0.2137872404691745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}