{"id":"W2008833812","doi":"10.1371/journal.pone.0089236","title":"IL-10-Producing B Cells Are Induced Early in HIV-1 Infection and Suppress HIV-1-Specific T Cell Responses","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; University of Toronto","funders":"National Institutes of Health; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Biology; Ex vivo; B cell; CD19; Immune system; Regulatory B cells; Immunology; T cell; In vivo; Interleukin 10; Virology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836674,0.0003736449,0.0002412372,0.0003872684,0.0001160307,0.0002681099,0.0001426519,0.0002369242,0.00142072],"category_scores_gemma":[0.0002183447,0.0002011033,0.0001296086,0.0001050135,0.0001798261,0.0001487342,0.000161209,0.0006508175,0.0004603373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171958,"about_ca_system_score_gemma":0.00009468952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002100036,"about_ca_topic_score_gemma":0.0002604058,"domain_scores_codex":[0.9998267,0.00003932501,0.00001018358,0.00002324457,0.00003663373,0.00006406424],"domain_scores_gemma":[0.9998037,0.00004722098,0.00004894842,0.00002111418,0.00001774535,0.000061263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206168,0.0000457373,0.001552651,0.00003386903,0.000006031382,0.00006654738,0.00002134537,0.00002731779,0.9952442,0.00004052146,0.0000319293,0.002809076],"study_design_scores_gemma":[0.00008313492,0.001557615,0.05770204,0.00004908792,0.00005139908,0.002221664,0.0000949781,0.0007563477,0.9319572,0.000219084,0.005298328,0.000009025832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925098,0.003919371,0.001866779,0.00006165983,0.00001827566,0.00003793488,0.000174892,0.0001054071,0.001305852],"genre_scores_gemma":[0.9943803,0.001493286,0.001764332,0.00006902731,0.00002606128,0.00005137248,0.0003568188,0.00002046164,0.001838348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142072,"threshold_uncertainty_score":0.004752755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04011658222293285,"score_gpt":0.2310090958821248,"score_spread":0.190892513659192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}