{"id":"W2008843662","doi":"10.1074/mcp.m114.047159","title":"The Last Enzyme of the De Novo Purine Synthesis Pathway 5-aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Plays a Central Role in Insulin Signaling and the Golgi/Endosomes Protein Network*","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation des Etoiles","keywords":"Endosome; Golgi apparatus; Chemistry; Cell biology; Purine; Purine metabolism; Enzyme; Biochemistry; Biology; Receptor; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565996,0.0003887565,0.00044545,0.0000434601,0.0002141425,0.00009781152,0.000697161,0.0002238744,0.000003727371],"category_scores_gemma":[0.0004794181,0.0002434493,0.0002548322,0.0002548903,0.0004682767,0.00001430229,0.00027165,0.0003720646,0.000001631995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006107163,"about_ca_system_score_gemma":0.0003490324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719466,"about_ca_topic_score_gemma":0.0003404755,"domain_scores_codex":[0.9969441,0.0007460399,0.0006296081,0.0004656684,0.0003814221,0.0008331938],"domain_scores_gemma":[0.9985715,0.00008059802,0.0002567981,0.0007946705,0.000105574,0.0001909144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006114828,0.00008864899,0.001223207,0.0000673684,0.0001478175,0.00001967793,0.0004619771,0.0102387,0.9813436,0.0008905717,0.00001118736,0.004895744],"study_design_scores_gemma":[0.002565752,0.00007553168,0.0002043263,0.00008635849,0.00008640814,0.00001493233,0.0001939739,0.004960309,0.9870462,0.001370183,0.003097992,0.0002980756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9354108,0.0596963,0.002685181,0.0001740586,0.00009925922,0.001793505,0.0000299694,0.00001638282,0.00009453121],"genre_scores_gemma":[0.9961898,0.001813301,0.0008430978,0.0002465961,0.0002274442,0.0005581259,0.00001501588,0.0000868942,0.00001970722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06077901,"threshold_uncertainty_score":0.9927574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004769387844404629,"score_gpt":0.1762421303062185,"score_spread":0.1714727424618139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}