{"id":"W2008843662","doi":"10.1074/mcp.m114.047159","title":"The Last Enzyme of the De Novo Purine Synthesis Pathway 5-aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Plays a Central Role in Insulin Signaling and the Golgi/Endosomes Protein Network*","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation des Etoiles","keywords":"Endosome; Golgi apparatus; Chemistry; Cell biology; Purine; Purine metabolism; Enzyme; Biochemistry; Biology; Receptor; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009767684,0.0005061031,0.0003344374,0.0003447839,0.0002916102,0.0005474341,0.000201341,0.0002914387,0.001142847],"category_scores_gemma":[0.0001203026,0.0001584886,0.0003393776,0.0002216399,0.0001819272,0.0002329525,0.0002200631,0.0003644271,0.0006712401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007283481,"about_ca_system_score_gemma":0.0002990824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856049,"about_ca_topic_score_gemma":0.001439664,"domain_scores_codex":[0.9998658,0.000008312145,0.00001065441,0.00005560453,0.00003200716,0.00002767314],"domain_scores_gemma":[0.9998878,0.00001066978,0.00003447941,0.0000130195,0.00002610483,0.00002788832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270588,0.00001773987,0.001400157,0.0000937177,0.00001557513,0.0001339445,0.00001191232,0.0001498183,0.9880427,0.0002459342,0.0001540748,0.00960731],"study_design_scores_gemma":[0.000008495546,0.00008818025,0.0103821,0.000005854287,0.00001826633,0.0006767891,0.00001492297,0.001265162,0.9785896,0.00007324223,0.008868529,0.000008746778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9230073,0.02348646,0.04151065,0.0004078775,0.0001758999,0.0001395573,0.002518683,0.001114539,0.007638881],"genre_scores_gemma":[0.9774451,0.002805218,0.01194778,0.00008617879,0.00002586861,0.00004560242,0.002132499,0.00005064741,0.005461114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856049,"threshold_uncertainty_score":0.005284607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004769387844404629,"score_gpt":0.1762421303062185,"score_spread":0.1714727424618139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}