{"id":"W2008865600","doi":"10.1182/blood.v95.10.3242","title":"Locus control region activity by 5′HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenes","year":2000,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Locus control region; Enhancer; Biology; Globin; Chromatin; Intron; Regulatory sequence; Transgene; Molecular biology; Gene; Promoter; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073124,0.0003599507,0.0001391674,0.0001212071,0.00009659035,0.0002385235,0.0001761034,0.0002029107,0.001230086],"category_scores_gemma":[0.0001274343,0.000170645,0.0002505806,0.00008260595,0.0002987415,0.000122072,0.0002302592,0.0005420499,0.0003578159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612162,"about_ca_system_score_gemma":0.0002038191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006783502,"about_ca_topic_score_gemma":0.001089663,"domain_scores_codex":[0.9998149,0.00002734045,0.0000139192,0.00005021227,0.00005619261,0.00003746375],"domain_scores_gemma":[0.9998487,0.00003833175,0.00004436996,0.00002058171,0.00001091981,0.00003699239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001483911,0.000005436839,0.0001084699,0.000004234166,0.000001181132,0.00000980117,0.00000531724,0.0000137259,0.9995136,0.00002611211,0.000003198809,0.0002939861],"study_design_scores_gemma":[0.000008932172,0.0001215856,0.004901291,0.000004125823,0.000008073795,0.0001916749,0.00001140975,0.0005021399,0.9934183,0.00002192219,0.0008083495,0.000002205401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935203,0.0002958402,0.00520347,0.00004163075,0.00001002089,0.00002060913,0.0001244652,0.00009026533,0.000693273],"genre_scores_gemma":[0.9927232,0.0001896689,0.004379063,0.00004857281,0.00000712983,0.00002954556,0.0006081397,0.00005642055,0.001958277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230086,"threshold_uncertainty_score":0.004115045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007092588456811795,"score_gpt":0.2380544600991122,"score_spread":0.2309618716423004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}