{"id":"W2008890975","doi":"10.1074/jbc.m400070200","title":"The C-terminal Domain Is the Primary Determinant of Histone H1 Binding to Chromatin in Vivo","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thunder Bay Regional Health Sciences Centre; University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Histone H1; Histone; Chromatin; C-terminus; Histone H3; Biology; Binding domain; Linker; Molecular biology; Biochemistry; Chemistry; Binding site; Cell biology; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005344908,0.0001406143,0.0002310073,0.00001685564,0.00008810142,0.00001888568,0.0005292505,0.0001662957,0.00001595284],"category_scores_gemma":[0.0001152962,0.00007371293,0.0001701642,0.00008908261,0.0001779462,0.000002477233,0.0001673299,0.0001913768,0.000001162801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009129427,"about_ca_system_score_gemma":0.0001359299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000413667,"about_ca_topic_score_gemma":0.000004689126,"domain_scores_codex":[0.9988816,0.00003341593,0.0005604051,0.0001547393,0.0001447045,0.0002251578],"domain_scores_gemma":[0.9991634,0.00004462666,0.0003975384,0.0002480277,0.00006986886,0.00007656102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056647,0.00006502637,0.0006030721,0.00002190022,0.00002031576,0.00003012973,0.0000783056,0.00005462886,0.998082,0.000008266367,0.0002022563,0.0007284505],"study_design_scores_gemma":[0.000653428,0.0004015609,0.003890863,0.00007968428,0.0000108626,0.0005942398,0.0002930253,0.00000750648,0.9881831,0.0004671112,0.005271295,0.0001473191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981567,0.000550984,0.0001313848,0.0006287935,0.0000684295,0.00008226863,0.00001601852,0.000001411298,0.0003639701],"genre_scores_gemma":[0.9976202,0.0003002078,0.001570401,0.000213334,0.0001542362,0.000004524869,0.00000396212,0.000008535864,0.0001246285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00989888,"threshold_uncertainty_score":0.3005926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008424342309463652,"score_gpt":0.2549652541453191,"score_spread":0.2465409118358555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}