{"id":"W2008898957","doi":"10.1038/sj.bjp.0704156","title":"Inhibition of poly (ADP‐ribose) synthetase by gene disruption or inhibition with 5‐iodo‐6‐amino‐1,2‐benzopyrone protects mice from multiple‐low‐dose‐streptozotocin‐induced diabetes","year":2001,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Streptozotocin; Internal medicine; Endocrinology; Biology; Poly ADP ribose polymerase; Programmed cell death; Cytokine; Islet; Peroxynitrite; Nitric oxide; Apoptosis; Nitric oxide synthase; Diabetes mellitus; Medicine; Biochemistry; Enzyme; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265834,0.0007214988,0.0003766738,0.0003744362,0.0001018615,0.0003309308,0.0003049739,0.0003246193,0.001054491],"category_scores_gemma":[0.0001100134,0.0002421874,0.0003304553,0.0001861361,0.0002569636,0.0002462953,0.0001325818,0.001049172,0.000375141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002652351,"about_ca_system_score_gemma":0.0002301975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003626908,"about_ca_topic_score_gemma":0.0005509318,"domain_scores_codex":[0.9998537,0.00001636022,0.00001508846,0.000038233,0.00003439374,0.00004207026],"domain_scores_gemma":[0.9996974,0.00002671243,0.0001547641,0.00002845884,0.00001300941,0.00007960619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000322794,0.00007746796,0.0001375873,0.00002374403,0.000006983355,0.00002507128,0.000007062446,0.00006849726,0.998318,0.00004680967,0.00002419196,0.0009418366],"study_design_scores_gemma":[0.00008110182,0.002188919,0.00457179,0.00001203888,0.00003210447,0.0001621651,0.00001829753,0.0007000358,0.9911705,0.00004290812,0.001012616,0.00000744851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937139,0.001501365,0.002905639,0.0001096651,0.00005172279,0.00003304007,0.0004890055,0.0002975053,0.0008982217],"genre_scores_gemma":[0.992197,0.001669248,0.002275626,0.00008124002,0.00002692983,0.0000573563,0.0009082869,0.00006079597,0.002723382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054491,"threshold_uncertainty_score":0.003527641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077084176565093,"score_gpt":0.2519969630684738,"score_spread":0.2412261213028229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}