{"id":"W2008914629","doi":"10.1021/bi7010866","title":"NMR Solution Structures of the Apo and Peptide-Inhibited Human Rhinovirus 3C Protease (Serotype 14):  Structural and Dynamic Comparison","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protease; Rhinovirus; Chemistry; Protein Data Bank (RCSB PDB); Protein structure; Cysteine protease; Stereochemistry; Peptide sequence; Enzyme; Biochemistry; Biology; Virus; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701558,0.0004438846,0.0003958234,0.0002126622,0.0002660884,0.0004170926,0.0005628166,0.0006174669,0.00170464],"category_scores_gemma":[0.0003588416,0.0002149662,0.0003337446,0.0003502225,0.0002639931,0.0003322801,0.0001460402,0.0006533578,0.0002806433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006809692,"about_ca_system_score_gemma":0.0004056788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003546152,"about_ca_topic_score_gemma":0.002663624,"domain_scores_codex":[0.9999253,0.00001322302,0.000003952544,0.00001528753,0.00002553353,0.0000167339],"domain_scores_gemma":[0.9998211,0.00004096453,0.00004248825,0.000008990959,0.00005255919,0.000033918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001847072,0.0003506237,0.005133161,0.0006032673,0.0002335092,0.0009764075,0.000571548,0.02986398,0.9389228,0.002774575,0.003912603,0.01481047],"study_design_scores_gemma":[0.0008015346,0.002522701,0.07154078,0.0001866671,0.0005273461,0.002247892,0.001535217,0.4332832,0.4509528,0.002937935,0.03314693,0.0003170893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874119,0.002100912,0.004970886,0.0003625153,0.00003381779,0.00002375925,0.001136867,0.000119349,0.003840056],"genre_scores_gemma":[0.9776902,0.002171092,0.0122866,0.0001825888,0.00002807713,0.00004578357,0.006002958,0.00006734025,0.001525437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003546152,"threshold_uncertainty_score":0.007050991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663668413717883,"score_gpt":0.3325480335654261,"score_spread":0.3159113494282472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}