{"id":"W2008914629","doi":"10.1021/bi7010866","title":"NMR Solution Structures of the Apo and Peptide-Inhibited Human Rhinovirus 3C Protease (Serotype 14):  Structural and Dynamic Comparison","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protease; Rhinovirus; Chemistry; Protein Data Bank (RCSB PDB); Protein structure; Cysteine protease; Stereochemistry; Peptide sequence; Enzyme; Biochemistry; Biology; Virus; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397811,0.0001081092,0.0001661656,0.00004405711,0.0001964593,0.00001343339,0.00005679598,0.0001505157,0.00003472174],"category_scores_gemma":[0.00008446507,0.00007527569,0.00003793171,0.0001212845,0.0004135215,0.00002902771,0.00009241621,0.0003074786,6.522091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000457725,"about_ca_system_score_gemma":0.0000411621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001374457,"about_ca_topic_score_gemma":0.00002526501,"domain_scores_codex":[0.9992864,0.00001902098,0.0002022664,0.0001793286,0.0001300885,0.0001829635],"domain_scores_gemma":[0.9995196,0.00001579164,0.00008503987,0.0002281498,0.00008815546,0.00006325718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001277968,0.00002473898,0.08677524,0.0001347876,0.00003440638,0.00000166575,0.00005491157,3.464202e-7,0.9110326,0.00003844539,0.0001304842,0.001644608],"study_design_scores_gemma":[0.0007183884,0.0001363307,0.4294938,0.00005499986,0.00003298917,0.00007513245,0.0001241344,0.0002368706,0.5688666,0.000132755,0.0000537942,0.00007416193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979483,0.00113203,0.00002118357,0.000156746,0.00003359618,0.0002803796,0.000009768805,0.00001983764,0.0003981018],"genre_scores_gemma":[0.9992737,0.00001253862,0.0001254908,0.00002335752,0.00003795989,0.000003913471,0.00002552638,0.000008499828,0.0004890179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3427186,"threshold_uncertainty_score":0.3069654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663668413717883,"score_gpt":0.3325480335654261,"score_spread":0.3159113494282472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}