{"id":"W2008979103","doi":"10.1085/jgp.116.1.1","title":"The Interaction of a Neutral Ryanoid with the Ryanodine Receptor Channel Provides Insights into the Mechanisms by Which Ryanoid Binding Is Modulated by Voltage","year":2000,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Heart, Lung, and Blood Institute; Wellcome Trust","keywords":"Ryanodine receptor; Biophysics; Chemistry; Endoplasmic reticulum; Membrane potential; Ion channel; Transmembrane protein; Dissociation constant; Receptor; Dissociation (chemistry); Dissociation rate; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004221722,0.0001934592,0.0001978224,0.00003268339,0.0004324779,0.00002871934,0.0004268537,0.0001278675,0.00005658688],"category_scores_gemma":[0.00002341486,0.00007548041,0.0001084341,0.0002048993,0.0002076469,0.00002181351,0.00005301829,0.0002700231,0.000006444207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002554292,"about_ca_system_score_gemma":0.0000528189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006703274,"about_ca_topic_score_gemma":0.00003766986,"domain_scores_codex":[0.9987015,0.0003612635,0.0003699982,0.0001664254,0.0001801379,0.0002206746],"domain_scores_gemma":[0.9988527,0.00005969963,0.0004612045,0.0002996377,0.0002810035,0.00004570388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001375271,0.00004444741,0.000001242051,0.000004373019,0.0001434944,1.084849e-7,0.001187537,0.004559107,0.965048,0.00002755029,0.02644707,0.001161809],"study_design_scores_gemma":[0.0006623613,0.001312147,0.00008578019,0.00001627418,0.0000594969,0.00003695803,0.001110583,0.004324112,0.9584556,0.0005722786,0.03323031,0.0001341403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913598,0.0007160972,0.00135196,0.005835922,0.0004485621,0.000221422,0.000008279548,0.000005192387,0.00005282181],"genre_scores_gemma":[0.9953816,0.001177465,0.00002291542,0.0007362575,0.0005744001,0.000009836606,0.00005290921,0.00002251061,0.002022135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00678324,"threshold_uncertainty_score":0.3326314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005933884226296794,"score_gpt":0.2160778891015813,"score_spread":0.2101440048752845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}