{"id":"W2009047479","doi":"10.1182/blood-2013-08-520445","title":"Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Heart and Stroke Foundation; University Health Network; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Cell biology; Stem cell; Progenitor cell; Biology; Paracrine signalling; Haematopoiesis; Hematopoietic stem cell; Cell fate determination; Cytokine; Immunology; Transcription factor; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833093,0.0001206049,0.0001348841,0.00004579538,0.0000552556,0.00002158294,0.0002347725,0.0001360881,0.00009247233],"category_scores_gemma":[0.00008182662,0.0001153175,0.00005853691,0.0001819733,0.00009199266,0.000006975639,0.0001197218,0.0000967435,0.00004891521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004982664,"about_ca_system_score_gemma":0.0000520161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000607635,"about_ca_topic_score_gemma":0.000004156603,"domain_scores_codex":[0.9987895,0.0000531099,0.0003004668,0.0003028684,0.0002595983,0.0002944834],"domain_scores_gemma":[0.9991155,0.00004256997,0.0001230076,0.0003652677,0.0001761437,0.0001775152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006828624,0.0003259414,0.0009035039,0.00003517162,0.00005361136,7.212178e-7,0.00001136642,0.000005486299,0.9954361,0.00001181072,0.002054137,0.001155263],"study_design_scores_gemma":[0.001038257,0.0001712745,0.001176636,0.0000135449,0.00003929328,0.000003288523,0.00002669566,0.0001125263,0.9933276,0.00007014193,0.003898058,0.0001226598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969037,0.000540095,0.001332248,0.0001920987,0.00001230208,0.0003453087,0.00007901753,0.00002139932,0.0005738733],"genre_scores_gemma":[0.9976324,0.0001199751,0.0009322018,0.00006194069,0.00007919375,0.0001102398,0.0005178911,0.00002332774,0.0005227817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002108535,"threshold_uncertainty_score":0.4702511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008954630519489014,"score_gpt":0.2371721535099328,"score_spread":0.2282175229904437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}