{"id":"W2009047479","doi":"10.1182/blood-2013-08-520445","title":"Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Heart and Stroke Foundation; University Health Network; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Cell biology; Stem cell; Progenitor cell; Biology; Paracrine signalling; Haematopoiesis; Hematopoietic stem cell; Cell fate determination; Cytokine; Immunology; Transcription factor; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076351,0.0003047312,0.0002006396,0.000257003,0.0001274863,0.0003631574,0.000216935,0.0002087063,0.001144526],"category_scores_gemma":[0.00007966883,0.0001570935,0.0001322143,0.00007896346,0.0003707662,0.0002061701,0.0002695323,0.0006411386,0.0002525118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005112145,"about_ca_system_score_gemma":0.0002402726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000651788,"about_ca_topic_score_gemma":0.001351744,"domain_scores_codex":[0.9998606,0.00001875319,0.000009211879,0.00003712975,0.00004601628,0.00002827486],"domain_scores_gemma":[0.9999223,0.00000956955,0.00002890754,0.000008248177,0.000008914809,0.00002193617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002711771,0.000004175656,0.00007906993,0.00001146494,9.046464e-7,0.00001722275,0.00001438905,0.00003688388,0.9987431,0.0001573813,0.00001425735,0.0008939318],"study_design_scores_gemma":[0.000007313574,0.00005180448,0.001378612,0.000003676507,0.000005627489,0.00006251544,0.00001970951,0.0006264073,0.9962882,0.00005234455,0.001500748,0.000003029622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989697,0.001385683,0.005755826,0.000167443,0.00003255666,0.00002690615,0.0002593101,0.0001377099,0.002537542],"genre_scores_gemma":[0.9913475,0.0007713228,0.003568142,0.00005873986,0.000008498414,0.00002579402,0.0001575556,0.00001943378,0.004043033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144526,"threshold_uncertainty_score":0.003828824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008954630519489014,"score_gpt":0.2371721535099328,"score_spread":0.2282175229904437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}