{"id":"W2009049031","doi":"10.1007/s00018-013-1406-1","title":"Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis","year":2013,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cathepsin B; Cathepsin L; Cathepsin; Proteases; Extracellular matrix; Cell biology; Matrix metalloproteinase; Zebrafish; Chemistry; Biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234619,0.0009248032,0.0005943607,0.001006965,0.0002455691,0.000866196,0.0002904155,0.0007698305,0.002173581],"category_scores_gemma":[0.0002586145,0.0003427609,0.0006332274,0.000289176,0.0005353398,0.0006722446,0.000452398,0.0008316098,0.0008209215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036216,"about_ca_system_score_gemma":0.0002254221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023239,"about_ca_topic_score_gemma":0.0003411934,"domain_scores_codex":[0.9996508,0.00003380454,0.00006041646,0.0001144638,0.00008266193,0.00005774135],"domain_scores_gemma":[0.9992932,0.00009123307,0.0002574065,0.00008961919,0.00004588358,0.0002226546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000312031,0.0000156843,0.0005167816,0.00002422582,0.00001485797,0.0003769883,0.000006418947,0.00003038707,0.9978324,0.0001305985,0.00004196299,0.0006977041],"study_design_scores_gemma":[0.00001906142,0.0001083005,0.003465955,0.000003304544,0.00002836365,0.002075812,0.00002446814,0.0004951392,0.9928232,0.0001290856,0.0008207172,0.000006519229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826172,0.001488497,0.0115361,0.000321899,0.000127468,0.00003234945,0.001624732,0.0005519533,0.001699748],"genre_scores_gemma":[0.9909921,0.0004323289,0.005084765,0.00008174829,0.00001936858,0.00002982406,0.0007819078,0.00007279975,0.002505185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173581,"threshold_uncertainty_score":0.007271349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281180825768321,"score_gpt":0.2378584230128006,"score_spread":0.2250466147551174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}