{"id":"W2009133933","doi":"10.1016/j.str.2006.03.009","title":"The Structure of I-CeuI Homing Endonuclease: Evolving Asymmetric DNA Recognition from a Symmetric Protein Scaffold","year":2006,"lang":"en","type":"article","venue":"Structure","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service; American Cancer Society","keywords":"Homing endonuclease; Endonuclease; Biology; DNA; Restriction enzyme; Recognition sequence; Homing (biology); Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211873,0.0002611011,0.0002280577,0.0001406778,0.0002506334,0.00007893264,0.0003620973,0.0003334404,0.0001106272],"category_scores_gemma":[0.000328357,0.000192554,0.0001438615,0.0005019176,0.00007484244,0.00001050177,0.0001019869,0.0001498573,0.000003666448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002452693,"about_ca_system_score_gemma":0.00006010861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00022201,"about_ca_topic_score_gemma":0.000141411,"domain_scores_codex":[0.9984314,0.0001445014,0.0003486999,0.0004342987,0.0003063683,0.0003346809],"domain_scores_gemma":[0.9989184,0.00006436372,0.0003002193,0.0005022863,0.0001537323,0.00006100177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006730914,0.00001064104,0.0002111369,0.00002119195,0.00005190258,0.000002180768,0.00001150336,0.000006488283,0.9466743,0.0002592343,0.000331372,0.05235273],"study_design_scores_gemma":[0.0004182862,0.0001050629,0.002855037,0.00004489632,0.000043615,0.00001047797,0.00005542013,0.00002371698,0.9772409,0.01604814,0.00291175,0.0002427571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926713,0.005094589,0.0003604026,0.00006006564,0.0002494592,0.0005003143,0.0004850403,0.00002107357,0.0005577716],"genre_scores_gemma":[0.9947846,0.00005008256,0.003995402,0.00004164323,0.0006386201,0.000009811381,0.0003000449,0.00004393349,0.0001358845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05210997,"threshold_uncertainty_score":0.7852126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005674436200130769,"score_gpt":0.1987531743750477,"score_spread":0.193078738174917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}