{"id":"W2009161907","doi":"10.1080/15287390903084314","title":"Efficient Knockdown of Human <i>prnp</i> mRNA Expression Levels Using Hybrid Hammerhead Ribozymes","year":2009,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health; University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"PRNP; Gene knockdown; Ribozyme; Biology; Messenger RNA; Virology; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003153314,0.0002421767,0.0002138614,0.00008855927,0.00009797778,0.0003368157,0.0001747335,0.0002351038,0.0006684471],"category_scores_gemma":[0.0002341986,0.0001248878,0.0001986557,0.00007004035,0.0002954936,0.0001382964,0.0001736964,0.0003192286,0.0002163138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302624,"about_ca_system_score_gemma":0.0001040926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001848431,"about_ca_topic_score_gemma":0.0003532247,"domain_scores_codex":[0.9997807,0.00005402585,0.00002989361,0.00005623959,0.00004614981,0.00003295116],"domain_scores_gemma":[0.9998474,0.00005741333,0.00004503098,0.00002145011,0.0000116586,0.00001694634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000334933,0.000006477096,0.00003967343,0.00001176117,0.000002944473,0.00001312308,0.00000809177,0.00005457272,0.999119,0.00008779843,0.0000138191,0.0006092822],"study_design_scores_gemma":[0.00001019453,0.000214091,0.0003933597,0.000001566916,0.000007600659,0.00007028002,0.000006920504,0.0005366727,0.9981018,0.0000292275,0.00062589,0.000002379902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879402,0.0004819919,0.01033637,0.00005918605,0.00002282637,0.00004076356,0.0001292881,0.0001252172,0.0008642466],"genre_scores_gemma":[0.9913038,0.000237817,0.007063116,0.00004448308,0.0000100721,0.0000334696,0.0002375142,0.0000286749,0.00104114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006684471,"threshold_uncertainty_score":0.002236128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246900283717781,"score_gpt":0.3164465050569482,"score_spread":0.2939775022197704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}