{"id":"W2009166249","doi":"10.1016/j.ccr.2012.01.021","title":"DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Faculty of Medicine and Dentistry, University of Alberta; Ministerstvo Zdravotnictví Ceské Republiky; Grantová Agentura České Republiky; Akademie Věd České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Danmarks Grundforskningsfond; Deutsche Forschungsgemeinschaft; European Commission; Kræftens Bekæmpelse","keywords":"DNA damage; Cell biology; Biology; Senescence; Progenitor cell; Cancer research; Transcription factor; Myeloid leukemia; Stem cell; DNA; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001266273,0.0001765287,0.000245436,0.0001141858,0.0001056675,0.00002453476,0.0001714206,0.0001390844,0.0004972246],"category_scores_gemma":[0.0001550525,0.000128876,0.0000534139,0.0002511773,0.0001062388,0.0001451771,0.0001358092,0.0003798875,0.00004186743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009709707,"about_ca_system_score_gemma":0.0006513762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619091,"about_ca_topic_score_gemma":0.0001307502,"domain_scores_codex":[0.9983726,0.0002734099,0.0002456018,0.0002459891,0.0003027995,0.0005596292],"domain_scores_gemma":[0.9987232,0.0004427899,0.00006596232,0.0004397775,0.0000671366,0.0002611514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001232804,0.00003316411,0.03293417,0.0001122882,0.00002709806,0.00007881742,0.002305032,0.00001081633,0.9598225,0.00001739008,0.001571932,0.001854026],"study_design_scores_gemma":[0.002621524,0.0001150267,0.150167,0.0001279603,0.0000762921,0.00002310811,0.001697147,0.0003379264,0.8199003,0.000007151668,0.02468779,0.0002388099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914277,0.003682757,0.000005297402,0.0009631641,0.0001428879,0.0004715656,0.000007098646,0.00003615598,0.003263419],"genre_scores_gemma":[0.9948969,0.00044739,0.00007307837,0.0008520965,0.0004422279,0.0001054983,0.00000161425,0.0000476854,0.003133542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1399222,"threshold_uncertainty_score":0.5444261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139910427728135,"score_gpt":0.2965980130578145,"score_spread":0.2651989087805331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}