{"id":"W2009166249","doi":"10.1016/j.ccr.2012.01.021","title":"DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Faculty of Medicine and Dentistry, University of Alberta; Ministerstvo Zdravotnictví Ceské Republiky; Grantová Agentura České Republiky; Akademie Věd České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Danmarks Grundforskningsfond; Deutsche Forschungsgemeinschaft; European Commission; Kræftens Bekæmpelse","keywords":"DNA damage; Cell biology; Biology; Senescence; Progenitor cell; Cancer research; Transcription factor; Myeloid leukemia; Stem cell; DNA; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003476831,0.0004405046,0.0003829603,0.0004520866,0.000278696,0.0007955131,0.0003246076,0.0006445899,0.004362374],"category_scores_gemma":[0.0002375349,0.0002338302,0.0002432767,0.0001313043,0.000407923,0.0005541032,0.0003946418,0.00201307,0.001368552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990963,"about_ca_system_score_gemma":0.0004092603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052834,"about_ca_topic_score_gemma":0.0006864278,"domain_scores_codex":[0.9995891,0.00008559662,0.00003256525,0.00005294165,0.00009536379,0.0001445127],"domain_scores_gemma":[0.999745,0.00004122296,0.00006177191,0.00004077099,0.00002032889,0.00009088883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008512116,0.0004901877,0.0002719402,0.00004452191,0.000009881776,0.00004617447,0.00003243078,0.0001635919,0.9939722,0.0007904966,0.0002405118,0.003086791],"study_design_scores_gemma":[0.000204394,0.001461869,0.00224235,0.0000153829,0.00002460113,0.0002065034,0.00009351622,0.002032259,0.9882522,0.0003042841,0.005156663,0.000005961252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886003,0.001904233,0.004467864,0.0005403017,0.00006506465,0.00007720725,0.0005739072,0.0002440165,0.00352714],"genre_scores_gemma":[0.9941503,0.0003726515,0.001450347,0.0001202805,0.00001986189,0.00004338004,0.0005530763,0.00002156226,0.003268401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004362374,"threshold_uncertainty_score":0.0145936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139910427728135,"score_gpt":0.2965980130578145,"score_spread":0.2651989087805331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}