{"id":"W2009170690","doi":"10.1089/hum.2006.17.353","title":"Insertional Mutagenesis at Positions 520 and 584 of Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Generation of AAV2 Vectors with Eliminated Heparin- Binding Ability and Introduced Novel Tropism","year":2006,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Cancer Research Society","keywords":"Tropism; Transduction (biophysics); Biology; Adeno-associated virus; Insertional mutagenesis; Capsid; Tissue tropism; Mutant; Mutagenesis; Gene; Virology; Molecular biology; Cell biology; Virus; Recombinant DNA; Vector (molecular biology); Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002505585,0.0002131557,0.0002670186,0.0001224046,0.0002293107,0.00002166609,0.00009229375,0.0001531893,0.00004027818],"category_scores_gemma":[0.0000148945,0.0001967355,0.0000409247,0.000172182,0.0002776475,0.00001022236,0.00006492117,0.00007535801,4.434673e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005260063,"about_ca_system_score_gemma":0.00007381241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003208666,"about_ca_topic_score_gemma":0.00133762,"domain_scores_codex":[0.998665,0.0001336763,0.0003107396,0.0004474939,0.0002127,0.0002304258],"domain_scores_gemma":[0.9992123,0.00001818713,0.0001665305,0.0002835352,0.0002472211,0.00007217797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001312121,0.0002415815,0.01331268,0.0000157323,0.000175668,0.000001292979,0.0001126614,0.0001227233,0.9842914,0.00001717529,0.00004259177,0.0003543657],"study_design_scores_gemma":[0.00191984,0.002391846,0.134682,0.000007121673,0.00002802228,0.00001511827,0.00001139042,0.0001046963,0.8606154,0.00002360072,0.00002373607,0.0001772393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968654,0.002521871,0.00004478059,0.0000561447,0.00002645991,0.0003321861,0.0001261182,0.00001220341,0.00001484084],"genre_scores_gemma":[0.9977783,0.0008897691,0.0003116722,0.00003859681,0.0001158185,0.00002089449,0.0007026185,0.00003727651,0.0001050468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.123676,"threshold_uncertainty_score":0.802264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727639181272883,"score_gpt":0.2726479048005846,"score_spread":0.2453715129878558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}