{"id":"W2009231148","doi":"10.1042/bj20081056","title":"The life of a cell: apoptosis regulation by the PI3K/PKB pathway","year":2008,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Kinase; Cell biology; Intracellular; Phosphoinositide 3-kinase; Signal transduction; Biology; Apoptosis; Programmed cell death; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454563,0.0007875733,0.00121863,0.001612094,0.0003624712,0.0007842261,0.0007565771,0.0008696073,0.002695214],"category_scores_gemma":[0.0002461974,0.0002147337,0.0002348578,0.001781317,0.0004398501,0.001329011,0.0005772219,0.001331902,0.004096634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007542806,"about_ca_system_score_gemma":0.0006224266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006152196,"about_ca_topic_score_gemma":0.001149353,"domain_scores_codex":[0.9998878,0.0000143282,0.00001582982,0.00002025549,0.00005096884,0.00001076625],"domain_scores_gemma":[0.9999107,0.00002235317,0.00001594173,0.000003264325,0.0000299024,0.00001781193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007420482,0.00005396524,0.0001497513,0.007202849,0.00004176295,0.0003307638,0.00007150262,0.000252087,0.004505726,0.004088542,0.03577046,0.9474584],"study_design_scores_gemma":[0.00001012839,0.00005264921,0.0006082317,0.000842683,0.00002642387,0.001477448,0.00005054994,0.00005429023,0.0007314326,0.001614294,0.9945227,0.000009218884],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002488475,0.9958835,0.0003245168,0.0004340189,0.000399597,0.000007615713,0.00001861158,0.00001684982,0.002666424],"genre_scores_gemma":[0.0009044129,0.9966707,0.0003452625,0.0001968886,0.0001952324,0.000008772377,0.00003053646,0.000001961433,0.001646254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002695214,"threshold_uncertainty_score":0.009016335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127170086122046,"score_gpt":0.2801464283449316,"score_spread":0.2588747274837111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}