{"id":"W2009232050","doi":"10.1073/pnas.161293598","title":"Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"Medical Research Council","keywords":"Galanin; Galanin receptor; Agonist; Neuropeptide; Nociception; Receptor; Neuropathic pain; Spinal cord; Endocrinology; Analgesic; Internal medicine; Medicine; Allodynia; Pharmacology; Chemistry; Hyperalgesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408353,0.000414993,0.0004137442,0.0001761721,0.00008596466,0.0002164796,0.0002326931,0.000284592,0.001308941],"category_scores_gemma":[0.0000985989,0.0001220153,0.0003489048,0.0001730214,0.0001760861,0.0002345673,0.0002149131,0.0005280645,0.0003153638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620429,"about_ca_system_score_gemma":0.00009548391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001130031,"about_ca_topic_score_gemma":0.0002229799,"domain_scores_codex":[0.9998754,0.00002176982,0.00001039148,0.0000236721,0.00002553391,0.00004329115],"domain_scores_gemma":[0.9999619,0.000004193018,0.00001368832,0.000005079793,0.000003998214,0.00001112526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001687655,0.00003130699,0.0001490451,0.00004426516,0.000004267529,0.00005090197,0.000007629672,0.000043872,0.997963,0.00003586781,0.00001546152,0.001485607],"study_design_scores_gemma":[0.00007666038,0.002312061,0.01095986,0.00001405073,0.00005040233,0.001633881,0.00004281124,0.0008289427,0.9822592,0.00006568358,0.00174519,0.00001138982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937698,0.002876702,0.001859401,0.00007157621,0.00001899894,0.00003583208,0.0001219872,0.00003502293,0.001210706],"genre_scores_gemma":[0.9941084,0.001929504,0.002243712,0.00008037914,0.00002186342,0.00004499767,0.0002162661,0.00000921775,0.001345591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308941,"threshold_uncertainty_score":0.004378855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1028991290415964,"score_gpt":0.3363926833231964,"score_spread":0.2334935542816001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}