{"id":"W2009266771","doi":"10.2174/156802611795429176","title":"Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?","year":2011,"lang":"en","type":"article","venue":"Current Topics in Medicinal Chemistry","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Broad Institute; Novartis Foundation","keywords":"Phenotypic screening; Disease; Phenotype; Computational biology; Medicine; Data science; Computer science; Biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007793342,0.0006217331,0.001966231,0.00174498,0.0003603278,0.002397643,0.001068373,0.001451541,0.007086161],"category_scores_gemma":[0.01272634,0.0002548006,0.0007251232,0.001810029,0.001676716,0.003821164,0.001215374,0.001186517,0.00153071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009008406,"about_ca_system_score_gemma":0.001059896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005125534,"about_ca_topic_score_gemma":0.0007878382,"domain_scores_codex":[0.9963157,0.00182065,0.0001301325,0.0002492703,0.001309588,0.0001746885],"domain_scores_gemma":[0.9933406,0.004646708,0.0006602925,0.0003490907,0.0007627591,0.0002405956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000608066,0.0005595823,0.01570229,0.004331582,0.0004015306,0.001475999,0.0003479053,0.02319198,0.009401291,0.1675027,0.02285948,0.7536176],"study_design_scores_gemma":[0.0007348551,0.006894544,0.03503815,0.002585208,0.0007866773,0.005443169,0.003354424,0.09806523,0.02747891,0.6435801,0.1756532,0.0003855849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1347176,0.1154264,0.5141719,0.1021235,0.002802971,0.001594009,0.001525464,0.001295694,0.1263424],"genre_scores_gemma":[0.7559677,0.08698203,0.1247883,0.01042137,0.001736047,0.0009853467,0.0006789909,0.0002199692,0.0182202],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007793342,"threshold_uncertainty_score":0.0412156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4963976006319916,"score_gpt":0.4357863922136876,"score_spread":0.06061120841830392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}