{"id":"W2009272942","doi":"10.4161/cc.28106","title":"The aggregation and inheritance of damaged proteins determines cell fate during mitosis","year":2014,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Mitosis; Cell biology; Cell division; Cell cycle; Cell; Cell growth; Asymmetric cell division; Proteasome; Somatic cell; Cell Cycle Protein; Cell fate determination; Inclusion bodies; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006121584,0.00009315521,0.00008219568,0.00002185742,0.000232635,0.00004360222,0.000161585,0.00001863296,0.00000410409],"category_scores_gemma":[0.000211344,0.00007237956,0.00002698809,0.0000960242,0.0001373067,0.00006507917,0.00006532019,0.00004928813,0.000007649042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004887286,"about_ca_system_score_gemma":0.000009231795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005179389,"about_ca_topic_score_gemma":0.000009118947,"domain_scores_codex":[0.999159,0.0001685613,0.0001401501,0.0002465186,0.0001346001,0.0001511358],"domain_scores_gemma":[0.99941,0.0001465046,0.0001076782,0.0002573648,0.00002815881,0.00005034867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001145393,0.00002891097,0.001922091,0.0000480376,3.151565e-7,7.924154e-7,0.00009885267,0.00008015288,0.996851,0.000009314751,0.000013559,0.000935504],"study_design_scores_gemma":[0.0002576544,0.00004180497,0.02342089,0.00001084767,0.00000528688,8.137413e-7,0.00001934484,0.0006087592,0.9752779,0.0001492024,0.0001309682,0.00007650832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983627,0.0001369052,0.00006391689,0.00005998108,0.00009116976,0.0002410507,0.000004642442,0.0000211466,0.001018555],"genre_scores_gemma":[0.9991153,0.00009352222,0.0001547271,0.00004871178,0.00004033762,0.00003089577,2.773559e-7,0.00001433758,0.0005018977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02157309,"threshold_uncertainty_score":0.2951553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065081734147054,"score_gpt":0.2122486282306069,"score_spread":0.2015978108891364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}