{"id":"W2009284265","doi":"10.1074/jbc.m701182200","title":"The Src-like Adaptor Protein 2 Regulates Colony-stimulating Factor-1 Receptor Signaling and Down-regulation","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Sick Kids Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Signal transducing adaptor protein; Cell biology; Granulocyte colony-stimulating factor receptor; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Receptor; Biology; Haematopoiesis; Phosphorylation; Chemistry; Stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295784,0.0006447284,0.0002517512,0.0002652361,0.0001802792,0.0004767273,0.0002333407,0.0002629566,0.001331008],"category_scores_gemma":[0.0001008389,0.0001708224,0.0003685592,0.0001991282,0.0001741163,0.0002060227,0.0003578702,0.000572144,0.0009304848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003890381,"about_ca_system_score_gemma":0.0002427794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003742065,"about_ca_topic_score_gemma":0.000605247,"domain_scores_codex":[0.9997681,0.00002641777,0.00001887923,0.00004140231,0.00007298683,0.00007235788],"domain_scores_gemma":[0.9999093,0.000006907865,0.00002844348,0.000007372525,0.00001974249,0.00002815987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005273391,0.00001364125,0.0001524901,0.00003281942,0.000003703134,0.0000949023,0.000009851808,0.00003153577,0.9981472,0.0001195925,0.0001089902,0.001232637],"study_design_scores_gemma":[0.00005559427,0.0001903747,0.02483447,0.00001903937,0.00002798926,0.0009143757,0.00006338664,0.003025049,0.9581768,0.0001460344,0.01253563,0.00001128966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772459,0.01019275,0.005121564,0.0003312078,0.0001496959,0.00006532116,0.0008160036,0.0004135041,0.005664026],"genre_scores_gemma":[0.9872738,0.003086812,0.002172027,0.0001039022,0.00004031411,0.00006732043,0.001011957,0.0000419883,0.006201861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331008,"threshold_uncertainty_score":0.004452646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853619373160478,"score_gpt":0.2342368140003203,"score_spread":0.2157006202687155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}