{"id":"W2009325269","doi":"10.1089/aid.2006.0178","title":"Efficacy And Safety of Three Doses of Tipranavir Boosted with Ritonavir in Treatment-Experienced HIV Type 1-Infected Patients","year":2007,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute","funders":"Boehringer Ingelheim","keywords":"Ritonavir; Medicine; Nausea; Adverse effect; Internal medicine; Vomiting; Gastroenterology; Pharmacokinetics; Viral load; Diarrhea; Protease inhibitor (pharmacology); Randomized controlled trial; Tolerability; Nelfinavir; Pharmacology; Virology; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009757575,0.0005837955,0.001671273,0.0002381465,0.0003734514,0.0005406023,0.0005403429,0.001002886,0.001096466],"category_scores_gemma":[0.001662802,0.0004202774,0.0008480557,0.0002743341,0.0005314912,0.0005729164,0.0002082209,0.00139304,0.000268413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459276,"about_ca_system_score_gemma":0.0003880746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003110734,"about_ca_topic_score_gemma":0.0006334417,"domain_scores_codex":[0.999302,0.0004070168,0.00006190479,0.00008822593,0.00006980563,0.00007093779],"domain_scores_gemma":[0.9992986,0.0001897632,0.0001861747,0.00006699087,0.00003238704,0.000226089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7779536,0.0261741,0.01518365,0.0004289681,0.00111473,0.0002839428,0.0002674923,0.002049346,0.03025331,0.0001303732,0.0006550078,0.1455055],"study_design_scores_gemma":[0.3811842,0.5656158,0.04536393,0.00004472063,0.0005803349,0.0004441866,0.00007032946,0.001639301,0.004003983,0.0001640949,0.0008244353,0.00006478548],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986702,0.0006816641,0.0001180601,0.00006401198,0.00001812649,0.0001124554,0.00005423925,0.00002205419,0.0002593371],"genre_scores_gemma":[0.9984949,0.0003179665,0.0005380358,0.0001751876,0.00005454908,0.0001576318,0.0001181698,0.000004640162,0.0001390208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671273,"threshold_uncertainty_score":0.005160391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0563091343121845,"score_gpt":0.36558009969294,"score_spread":0.3092709653807555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}