{"id":"W2009419809","doi":"10.1128/aac.00348-13","title":"Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and Their Interactions with the M184I Mutation on Defining Patterns of Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research","keywords":"Rilpivirine; Etravirine; Reverse transcriptase; Reverse-transcriptase inhibitor; Virology; Human immunodeficiency virus (HIV); Resistance mutation; Nucleoside Reverse Transcriptase Inhibitor; Mutation; Drug resistance; Biology; Genetics; Sida; Viral disease; Antiretroviral therapy; RNA; Gene; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137321,0.0001850856,0.0002771657,0.000138933,0.00008942409,0.00001525707,0.00002753236,0.00003774702,0.00005971712],"category_scores_gemma":[0.000005953531,0.0001165045,0.00004227496,0.0001436958,0.00007859316,0.000108023,0.000007962612,0.0000903867,0.000002925618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003729993,"about_ca_system_score_gemma":0.00001204781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001898424,"about_ca_topic_score_gemma":0.0002776977,"domain_scores_codex":[0.9992471,0.00006004999,0.0002444834,0.0002267183,0.0000893694,0.0001323129],"domain_scores_gemma":[0.9996157,0.00007468979,0.00008761508,0.0001128337,0.0000403636,0.00006882957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007768386,0.001169718,0.258782,0.001137923,0.0006899998,0.0001053156,0.05683342,0.00004116047,0.618876,0.00005886112,0.02695388,0.02758325],"study_design_scores_gemma":[0.0178227,0.001783278,0.3540723,0.002754478,0.0003535943,0.0001212632,0.002140831,0.00009832951,0.6129869,0.00001304715,0.00741632,0.0004369421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880461,0.00002975818,0.0000737414,0.01087661,0.00002547406,0.0007793056,0.00009441617,0.000009343901,0.00006532069],"genre_scores_gemma":[0.9971498,0.0002298824,0.0003294678,0.001268851,0.00001118449,0.00003112912,0.0001156888,0.00001989847,0.0008441067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09529026,"threshold_uncertainty_score":0.4750914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004679426358660938,"score_gpt":0.2260923867380987,"score_spread":0.2214129603794378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}