{"id":"W2009419809","doi":"10.1128/aac.00348-13","title":"Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and Their Interactions with the M184I Mutation on Defining Patterns of Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research","keywords":"Rilpivirine; Etravirine; Reverse transcriptase; Reverse-transcriptase inhibitor; Virology; Human immunodeficiency virus (HIV); Resistance mutation; Nucleoside Reverse Transcriptase Inhibitor; Mutation; Drug resistance; Biology; Genetics; Sida; Viral disease; Antiretroviral therapy; RNA; Gene; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002800369,0.0003170049,0.0003137086,0.000249553,0.00008927549,0.000243971,0.0001974089,0.0003468428,0.001285037],"category_scores_gemma":[0.0008074374,0.0001585544,0.0002692686,0.0002167171,0.0002103836,0.0001818176,0.0001323974,0.0003864852,0.0001948037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104317,"about_ca_system_score_gemma":0.0001198345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004869762,"about_ca_topic_score_gemma":0.0006654038,"domain_scores_codex":[0.9995708,0.0001571028,0.00004716435,0.00007120687,0.00009811743,0.00005565581],"domain_scores_gemma":[0.999558,0.0001855,0.0001207363,0.00002631379,0.00002818108,0.00008122249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002611661,0.0006173128,0.01774919,0.00004809786,0.0001137397,0.0004447737,0.00006087704,0.0005144862,0.9682736,0.00009964254,0.00009822522,0.009368476],"study_design_scores_gemma":[0.0003227933,0.0143156,0.1882946,0.00002566123,0.0002569442,0.004679671,0.0001862448,0.004981566,0.7839848,0.0001334822,0.002773822,0.00004474719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993888,0.0001829891,0.00008176328,0.0000123731,0.000003866766,0.000008593994,0.00004939139,0.000004200402,0.0002681066],"genre_scores_gemma":[0.999404,0.00007421281,0.0002703547,0.00001402846,0.000003561097,0.000005546826,0.00007007329,0.000004954756,0.0001533164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285037,"threshold_uncertainty_score":0.004298925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004679426358660938,"score_gpt":0.2260923867380987,"score_spread":0.2214129603794378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}