{"id":"W2009445215","doi":"10.1371/journal.pcbi.1000944","title":"Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Royal Society; Alzheimer's Research Trust","keywords":"Proteasome; Cell biology; Cytotoxicity; Inclusion bodies; Programmed cell death; Reactive oxygen species; Chemistry; Cell; Biology; Biochemistry; Apoptosis; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004491883,0.0001264568,0.0002384023,0.0002960619,0.00008602541,0.00001324003,0.0001346229,0.00005435243,0.0001991751],"category_scores_gemma":[0.0003848274,0.0001200956,0.00006992165,0.0004673083,0.0004379145,0.00004252758,0.00008280013,0.0001005954,0.00001249739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007565965,"about_ca_system_score_gemma":0.00005532656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006466938,"about_ca_topic_score_gemma":0.000002835415,"domain_scores_codex":[0.9988735,0.0001443563,0.0002580174,0.0003938268,0.0001840391,0.0001463152],"domain_scores_gemma":[0.9985843,0.001005391,0.0001257547,0.00009712012,0.00009446949,0.00009300393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002204876,0.0002502318,0.02011164,0.000002753653,0.00007318037,0.000001545564,0.00007072849,0.0149738,0.9559241,0.008523707,0.00001011892,0.00003613842],"study_design_scores_gemma":[0.0003072102,0.0000947039,0.1749993,9.010493e-7,0.00006394189,0.000004552274,0.00001098351,0.1827135,0.6400876,0.001603615,0.000006494312,0.0001071893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996521,0.00002024606,0.002562742,0.0001373443,0.00007713088,0.0001340248,0.000420095,0.00003369138,0.00009372327],"genre_scores_gemma":[0.9956962,7.645017e-7,0.003466483,0.0005650347,0.0000258227,0.00001482023,0.0002166108,0.000008011367,0.000006182821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3158365,"threshold_uncertainty_score":0.4897358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274062873899579,"score_gpt":0.2912573554369456,"score_spread":0.2638510680469877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}