{"id":"W2009445215","doi":"10.1371/journal.pcbi.1000944","title":"Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Royal Society; Alzheimer's Research Trust","keywords":"Proteasome; Cell biology; Cytotoxicity; Inclusion bodies; Programmed cell death; Reactive oxygen species; Chemistry; Cell; Biology; Biochemistry; Apoptosis; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005266041,0.0004881586,0.0007478481,0.0006053777,0.0006037842,0.0007203117,0.0009896694,0.001132198,0.002855736],"category_scores_gemma":[0.002804152,0.0003480937,0.0006776432,0.0005505951,0.0006304387,0.0005215344,0.0004031182,0.0006470939,0.000156277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001194942,"about_ca_system_score_gemma":0.0012489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0154898,"about_ca_topic_score_gemma":0.00662691,"domain_scores_codex":[0.9998258,0.00004126598,0.00001348317,0.00003211472,0.00004557641,0.00004193158],"domain_scores_gemma":[0.9973716,0.001931222,0.0001428881,0.0001508943,0.000326177,0.00007726988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003456986,0.00003731354,0.0009567427,0.00004983203,0.00001339867,0.00005193986,0.00001378247,0.99484,0.0007769226,0.00216407,0.0002633321,0.0007981459],"study_design_scores_gemma":[0.00001032146,0.00001233089,0.000273377,0.000001920439,0.000003759504,0.000006175816,0.000006609565,0.9984941,0.0003567229,0.0007297051,0.0001018608,0.000003131549],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681556,0.0004077163,0.01442784,0.0007902815,0.00006570212,0.00006136054,0.001571445,0.0004280965,0.01409202],"genre_scores_gemma":[0.9928826,0.000113047,0.005429838,0.00005949173,0.00001235706,0.0001084965,0.000633298,0.00004321759,0.0007176763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154898,"threshold_uncertainty_score":0.03079927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274062873899579,"score_gpt":0.2912573554369456,"score_spread":0.2638510680469877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}