{"id":"W2009454954","doi":"10.1016/j.freeradbiomed.2008.09.013","title":"Insulin stimulation of γ-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose","year":2008,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Research Council Canada; National Institutes of Health; University of Wisconsin-Madison","keywords":"Oxidative stress; Stimulation; Protein subunit; Internal medicine; Glutathione; Endocrinology; Chemistry; Insulin; Ubiquitin ligase; Cell biology; Biochemistry; Biology; Medicine; Ubiquitin; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053291,0.0003307592,0.0004435437,0.000149138,0.0001530779,0.0004895409,0.000236486,0.0003264535,0.001644924],"category_scores_gemma":[0.0002713744,0.0002481059,0.0003638569,0.0002012406,0.000393271,0.0003568335,0.0002134422,0.0008827035,0.000275599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004284126,"about_ca_system_score_gemma":0.0002491955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108929,"about_ca_topic_score_gemma":0.001219415,"domain_scores_codex":[0.9998327,0.00003052756,0.00001620917,0.00004683797,0.00001833859,0.0000553078],"domain_scores_gemma":[0.9997823,0.0000399435,0.00003350441,0.00004472641,0.00002037942,0.00007922334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009713733,0.0001481478,0.0005979293,0.00004317334,0.00001946418,0.00008577801,0.00003855698,0.00004857419,0.9872671,0.0001128694,0.0001417738,0.00178285],"study_design_scores_gemma":[0.0002400874,0.0009921219,0.01619266,0.00001043711,0.00007506318,0.0001419583,0.000114587,0.0008923623,0.9801633,0.0001071168,0.001059403,0.00001101516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960211,0.00142663,0.001139205,0.0002566589,0.0001217774,0.00001281356,0.0002651159,0.00005973502,0.0006969875],"genre_scores_gemma":[0.9962394,0.0005400868,0.000625057,0.0001361711,0.00002488278,0.00002680321,0.0003566711,0.00002154165,0.00202937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644924,"threshold_uncertainty_score":0.00550276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008440073316408695,"score_gpt":0.2466958248782941,"score_spread":0.2382557515618854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}