{"id":"W2009457093","doi":"10.1038/srep04231","title":"Antisense Oligonucleotides Targeting Parasite Inositol 1,4,5-Trisphosphate Receptor Inhibits Mammalian Host Cell Invasion by Trypanosoma cruzi","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Trypanosoma cruzi; Chagas disease; Inositol; Biology; Intracellular; Receptor; Oligonucleotide; Parasite hosting; Cell biology; Virology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511594,0.0003165033,0.0002854515,0.000186232,0.0001352379,0.0001776321,0.0001836842,0.0002720278,0.001146846],"category_scores_gemma":[0.0001597757,0.0001159231,0.0001553598,0.00009702126,0.0002298742,0.0001158951,0.0001104483,0.0005353579,0.000247005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587865,"about_ca_system_score_gemma":0.0002025226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005649778,"about_ca_topic_score_gemma":0.00138993,"domain_scores_codex":[0.9998814,0.00001916042,0.00001420343,0.00002223859,0.00003117265,0.00003174779],"domain_scores_gemma":[0.9999057,0.00003531356,0.00002025013,0.000007200864,0.00001147083,0.00002011266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006415654,0.00002294899,0.00002502072,0.00002268913,0.000002601554,0.00001353846,0.00001048298,0.00002801429,0.9988487,0.0000520911,0.00002908151,0.0008806383],"study_design_scores_gemma":[0.00004637917,0.001375595,0.001109687,0.00000728206,0.00002813133,0.000133655,0.00002428574,0.0006653023,0.9945983,0.00003937125,0.001967602,0.000004544571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924016,0.002251202,0.002869922,0.0001270204,0.0000712329,0.00004441168,0.0001215668,0.0001267264,0.001986358],"genre_scores_gemma":[0.9910517,0.002375749,0.00325731,0.0001063298,0.00004149675,0.00007248917,0.00034993,0.00002907754,0.002715963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146846,"threshold_uncertainty_score":0.003836632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059036928702637,"score_gpt":0.2570513271215551,"score_spread":0.2464609578345287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}