{"id":"W2009497825","doi":"10.1038/bjc.2011.13","title":"Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours","year":2011,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Toronto; Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Histone deacetylase inhibitor; Histone deacetylase; Medicine; Pharmacology; Internal medicine; Histone; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007429895,0.00115279,0.001547686,0.0003277411,0.0003945303,0.0005716776,0.0005309944,0.0006341608,0.002411156],"category_scores_gemma":[0.0005472463,0.0004316978,0.0007019938,0.0004493664,0.0006533798,0.0004596962,0.0002811189,0.002316977,0.0007730924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000802613,"about_ca_system_score_gemma":0.001278875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008298213,"about_ca_topic_score_gemma":0.001750319,"domain_scores_codex":[0.9997206,0.0001043838,0.00001721646,0.00005655336,0.00004853545,0.00005274722],"domain_scores_gemma":[0.9995467,0.00005780928,0.0001276127,0.00003952844,0.00004204559,0.0001862257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3344934,0.08308791,0.01962218,0.001325516,0.00158297,0.0008116785,0.0006556414,0.009019801,0.3302326,0.0003684696,0.007122544,0.2116773],"study_design_scores_gemma":[0.1130244,0.8196191,0.03690316,0.00004851494,0.0005499079,0.0009334161,0.00008237706,0.002207726,0.0198009,0.0002108843,0.006578724,0.0000409948],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918161,0.00263257,0.001014646,0.0003032182,0.00005316818,0.001514418,0.001102931,0.0001003574,0.001462584],"genre_scores_gemma":[0.9909995,0.001689933,0.001980955,0.0003528013,0.000064916,0.001188446,0.001920034,0.0000274272,0.001775946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002411156,"threshold_uncertainty_score":0.008066118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307402772521,"score_gpt":0.392730181775085,"score_spread":0.369656154049875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}