{"id":"W2009546110","doi":"10.1021/jo001251t","title":"Mimicry of Peptide Backbone Geometry and Heteroatomic Side-Chain Functionality:  Synthesis of Enantiopure Indolizidin-2-one Amino Acids Possessing Alcohol, Acid, and Azide Functional Groups","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Hydroxymethyl; Side chain; Enantiopure drug; Azide; Alcohol; Amino acid; Sodium hydride; Sodium azide; Stereochemistry; Organic chemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009929598,0.0003566565,0.0001872623,0.0001128849,0.00007197816,0.0001710267,0.0002904263,0.0002629829,0.0006757572],"category_scores_gemma":[0.00009964418,0.000142044,0.0001757203,0.0001174552,0.0001051589,0.0001800615,0.0001717472,0.0002964773,0.0004210512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017063,"about_ca_system_score_gemma":0.0001122396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840664,"about_ca_topic_score_gemma":0.00052395,"domain_scores_codex":[0.9999299,0.000009348156,0.000005843431,0.00001668595,0.00001651875,0.00002169511],"domain_scores_gemma":[0.9999169,0.000006557779,0.00003027458,0.00001037193,0.00001021976,0.00002564252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002664066,0.000008767705,0.00004443806,0.00001918121,0.000002782392,0.0000452164,0.000009406923,0.0000982738,0.9986387,0.00009689952,0.000008852725,0.001000865],"study_design_scores_gemma":[0.00001495016,0.0001661023,0.0006909029,0.000002528394,0.00000867886,0.0001438693,0.000007905554,0.0005217703,0.9964946,0.00002232176,0.001920662,0.000005682574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899756,0.0007742671,0.005951457,0.00004321048,0.00002651198,0.00006203113,0.0001666039,0.00005445278,0.002945811],"genre_scores_gemma":[0.988043,0.0006981863,0.008999412,0.00003044615,0.00001011975,0.00004038529,0.000142324,0.00001989562,0.002016369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006757572,"threshold_uncertainty_score":0.002260685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288566282918417,"score_gpt":0.2182062303865912,"score_spread":0.2053205675574071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}