{"id":"W2009623159","doi":"10.1158/1078-0432.ccr-08-1916","title":"Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Temozolomide; Dacarbazine; Melanoma; Methyltransferase; Medicine; Cancer research; DNA methylation; Methylation; Oncology; Gene expression; Biology; Gene; Glioma; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003081925,0.0001037554,0.0003360824,0.000270921,0.00005181907,0.00002662284,0.0001025868,0.0001200458,0.00003473593],"category_scores_gemma":[0.00173664,0.00008378561,0.00006263182,0.0003981475,0.0001065381,0.00002520344,0.00009088632,0.0004643211,0.00005275027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291408,"about_ca_system_score_gemma":0.000349392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001312565,"about_ca_topic_score_gemma":0.00004732367,"domain_scores_codex":[0.9978242,0.0004499003,0.0004092666,0.0004746396,0.000395479,0.000446493],"domain_scores_gemma":[0.9983051,0.000759106,0.00002570602,0.0003390918,0.0001269186,0.0004440338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01089922,0.0007945277,0.8269141,0.00003331657,0.00005302349,0.001989085,0.0001378055,0.00001843165,0.1119705,0.0001772037,0.002204124,0.04480864],"study_design_scores_gemma":[0.003476391,0.002824834,0.9753288,0.0001818817,0.00001800894,0.0000140445,0.00004346295,0.0001204399,0.01495721,0.0002469283,0.002706204,0.00008181227],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973686,0.002224493,0.000002501537,0.02254304,0.00004880874,0.001026909,0.000007776535,0.00002598916,0.0004344913],"genre_scores_gemma":[0.9972035,0.0004774142,0.0005948001,0.00132633,0.0001146224,0.0001727943,0.000003335143,0.00001476458,0.00009241908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1484146,"threshold_uncertainty_score":0.3416678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1430902057841792,"score_gpt":0.5072967140975089,"score_spread":0.3642065083133297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}