{"id":"W2009623159","doi":"10.1158/1078-0432.ccr-08-1916","title":"Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Temozolomide; Dacarbazine; Melanoma; Methyltransferase; Medicine; Cancer research; DNA methylation; Methylation; Oncology; Gene expression; Biology; Gene; Glioma; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464035,0.0001654786,0.0002408763,0.0003719793,0.00006941479,0.0002503373,0.0000908179,0.0002344229,0.0007254871],"category_scores_gemma":[0.0006698502,0.00009695052,0.00008479608,0.0002530333,0.0001134014,0.0001141831,0.0001049707,0.0002075874,0.0001748827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001191655,"about_ca_system_score_gemma":0.00007280468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004087986,"about_ca_topic_score_gemma":0.0005985874,"domain_scores_codex":[0.9999143,0.00001928202,0.000007632389,0.00002773247,0.0000187184,0.00001228944],"domain_scores_gemma":[0.9997416,0.00009284711,0.0000901771,0.00001204874,0.00003038786,0.00003286281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001254155,0.0001441852,0.7294268,0.00008126865,0.00008684472,0.0001184306,0.00005704853,0.00126775,0.2510351,0.00003581761,0.0002252082,0.01626744],"study_design_scores_gemma":[0.00001588875,0.00042924,0.964212,0.000007444895,0.00005612163,0.000525379,0.00005561675,0.003115234,0.03099971,0.00006225389,0.0005163735,0.000004724228],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986797,0.0004223706,0.0003704516,0.00002560781,0.000001778436,0.00000736797,0.0003231562,0.00001201479,0.0001574658],"genre_scores_gemma":[0.9982456,0.000216892,0.0006925212,0.00002740845,0.000004280429,0.0000117514,0.0006236595,0.000002886886,0.0001750051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007254871,"threshold_uncertainty_score":0.002426982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1430902057841792,"score_gpt":0.5072967140975089,"score_spread":0.3642065083133297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}