{"id":"W2009627530","doi":"10.1074/jbc.m113.540799","title":"Roles for the Mitogen-activated Protein Kinase (MAPK) Phosphatase, DUSP1, in Feedback Control of Inflammatory Gene Expression and Repression by Dexamethasone","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Psychological repression; Gene silencing; Gene knockdown; CXCL1; Biology; Cell biology; Gene expression; Molecular biology; Phosphatase; Regulation of gene expression; Chemistry; Kinase; Chemokine; Inflammation; Biochemistry; Gene; Immunology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000706743,0.0001945133,0.0003389328,0.00001584686,0.00005755133,0.00001553274,0.0003067205,0.0003003681,0.0000149887],"category_scores_gemma":[0.001609422,0.0001168432,0.0001174795,0.0000565675,0.0002091533,0.00001019137,0.0001195857,0.0001821388,1.459832e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001474359,"about_ca_system_score_gemma":0.00004355963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003859709,"about_ca_topic_score_gemma":4.891515e-7,"domain_scores_codex":[0.9987074,0.000112945,0.0005476387,0.0002717683,0.0001458254,0.0002144866],"domain_scores_gemma":[0.9986427,0.0001806032,0.0006290994,0.0002892754,0.0001514789,0.000106805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001921957,0.00009473018,0.001767076,0.00006199977,0.00003631565,0.000002599868,0.000006464561,0.0000303234,0.9926314,0.000006297253,0.0008543597,0.002586469],"study_design_scores_gemma":[0.002705633,0.0003650764,0.0007225415,0.000143662,0.00001814455,0.00002148258,0.00002910411,0.0000426009,0.9909974,0.0001036021,0.004705102,0.0001457011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588775,0.0370173,0.003428078,0.0001399728,0.00003701046,0.0003458466,0.0001436142,0.000004202753,0.000006491819],"genre_scores_gemma":[0.9978044,0.0004809788,0.001306183,0.00006959216,0.0001720479,0.00004963055,0.00007803291,0.00001321078,0.00002594516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03892689,"threshold_uncertainty_score":0.4764727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00900276932945152,"score_gpt":0.2317493201897623,"score_spread":0.2227465508603108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}