{"id":"W2009641790","doi":"10.1016/s0378-5173(02)00183-7","title":"Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs","year":2002,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Drug carrier; Polymer; Chemistry; Cytoplasm; Drug delivery; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855707,0.0001210777,0.0001291367,0.0001065708,0.00003214269,0.0000230001,0.0004676481,0.00006060103,0.0001202753],"category_scores_gemma":[0.00006770028,0.00009309738,0.0001928557,0.00006354956,0.00007880815,0.00001032566,0.00007873635,0.0001589824,0.00002121456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003751347,"about_ca_system_score_gemma":0.00009727813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000219501,"about_ca_topic_score_gemma":0.000005914316,"domain_scores_codex":[0.9989449,0.00006041185,0.0003457329,0.0001267507,0.000380006,0.0001422348],"domain_scores_gemma":[0.9986959,0.00004250421,0.0002598083,0.0001300686,0.0007672955,0.0001044632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000415889,0.00007317863,0.0003011326,0.000003342811,0.0003870825,0.0000302253,0.0004760005,0.0006635053,0.9865633,0.00001948607,0.002443306,0.008623586],"study_design_scores_gemma":[0.0007899183,0.0003025732,0.00007512738,0.00003086058,0.0000629561,0.00008823736,0.0004204737,0.001759784,0.9781399,0.00001185531,0.01821721,0.000101063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942268,0.0006199145,0.0008664155,0.002175489,0.0009992967,0.00007945261,0.00006919774,0.000002139689,0.0009613138],"genre_scores_gemma":[0.9949831,0.000319905,0.0001515529,0.003545854,0.0004470757,0.000001912403,0.000005521408,0.00001277519,0.0005322585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0157739,"threshold_uncertainty_score":0.3796401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660423766567442,"score_gpt":0.2968726023119941,"score_spread":0.2802683646463197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}